# Benign Leydig cell tumor presenting in a solitary testis with cryptorchidism: A case report

**Authors:** Farzad Allameh, Sina Samenezhad, Lena Yaghoubpour, Amirhossein ghasemzade

PMC · DOI: 10.1016/j.eucr.2025.103232 · 2025-10-01

## TL;DR

A rare case of a non-cancerous Leydig cell tumor in a man with a single, undescended testis was successfully treated with surgery that preserved testicular function.

## Contribution

This case highlights the effectiveness of testis-sparing surgery for benign Leydig cell tumors in cryptorchid testes.

## Key findings

- A 52-year-old man with a history of cryptorchidism was diagnosed with a benign Leydig cell tumor.
- Partial orchiectomy preserved testicular function and ensured no recurrence.
- Histopathology and immunohistochemistry confirmed the benign nature of the tumor.

## Abstract

Leydig cell tumors (LCTs) are uncommon testicular neoplasms, accounting for 1–3 % of cases. While most are benign, a small subset demonstrates malignant potential, making accurate diagnosis and tailored management essential. We report the case of a 52-year-old man with a history of cryptorchidism and prior orchiectomy who presented with inguinal pain and infertility. Imaging revealed a solitary testis with a small intratesticular lesion. Intraoperative frozen section suggested a Leydig cell tumor, and partial orchiectomy was performed. Final pathology confirmed a benign LCT. The patient remains recurrence-free at follow-up, highlighting the role of testis-sparing surgery in selected cases.

•Rare case of benign Leydig cell tumor in a solitary, cryptorchid testis.•Left partial orchiectomy performed with hernia repair and testis repositioning.•Histopathology and immunohistochemistry confirmed benign Leydig cell tumor.•Testis-sparing surgery ensured hormonal preservation and recurrence-free follow-up.

Rare case of benign Leydig cell tumor in a solitary, cryptorchid testis.

Left partial orchiectomy performed with hernia repair and testis repositioning.

Histopathology and immunohistochemistry confirmed benign Leydig cell tumor.

Testis-sparing surgery ensured hormonal preservation and recurrence-free follow-up.

## Linked entities

- **Diseases:** cryptorchidism (MONDO:0009047), Leydig cell tumor (MONDO:0006266)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** infertility (MESH:D007246), testicular neoplasms (MESH:D013736), inguinal pain (MESH:D010146), Benign Leydig cell tumor (MESH:D007984), cryptorchidism (MESH:D003456)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12519295/full.md

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Source: https://tomesphere.com/paper/PMC12519295