LinTT1-Functionalized Hybrid Lipid–Polymer Nanoparticles for Glioblastoma Targeting
Antonella Rocchi, Valeria Sidorenko, Nicola d’Avanzo, Luca Marchetti, Jhalak Sethi, Luigi Ciriolo, Anna Maria Tolomeo, Maria Grazia Cifone, Paola Palumbo, Massimo Fresta, Tambet Teesalu, Christian Celia
TL;DR
Researchers developed a new nanoparticle system that targets glioblastoma brain tumors more effectively, improving drug delivery and treatment outcomes.
Contribution
A novel hybrid lipid-polymer nanoparticle functionalized with LinTT1 peptide for targeted glioblastoma drug delivery is introduced.
Findings
LinTT1-HLPNs bind selectively to glioblastoma cells in vitro and enhance the cytotoxicity of temozolomide.
In vivo, LinTT1-HLPNs improve TMZ accumulation in tumor areas in murine glioblastoma models.
The nanoplatform combines lipid-polymer benefits with a targeting strategy to address glioblastoma challenges.
Abstract
Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited therapeutic options and a poor prognosis. We developed hybrid lipid-polymer nanoparticles (HLPNs) functionalized with tumor-homing C-end Rule peptide LinTT1 (LinTT1-HLPNs) to improve the GBM targeting. In vitro studies demonstrated that LinTT1-HLPNs bind selectively to GBM cells and significantly improved the cytotoxicity of the loaded temozolomide (TMZ) (LinTT1-HLPNs@TMZ) compared to that of the free drug. In vivo, intravenous injection of HLPNs in both infiltrative and noninfiltrative GBM murine models had an enhanced accumulation of TMZ in the tumor area, thus endorsing the selective targeting and tissue penetration of LinTT1-HLPNs. This nanoplatform combines the advantages of hybrid lipid–polymer nanoparticles with a GBM-specific targeting strategy, thus providing an improved drug delivery and therapeutic effect…
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Taxonomy
TopicsRNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · MicroRNA in disease regulation