# A multimodal digital twin for autonomous micro-drilling in scientific exploration

**Authors:** Saul Alexis Heredia Perez, Tze Lun Lok, Enduo Zhao, Kanako Harada

PMC · DOI: 10.1007/s11548-025-03465-3 · 2025-06-26

## TL;DR

A digital twin was created to simulate micro-drilling for scientific research, producing realistic images and sounds for training AI models.

## Contribution

A multimodal digital twin combining visual and audio realism for autonomous micro-drilling is developed and validated.

## Key findings

- The DAG model outperformed pitch modulation methods with lower FAD and FID scores, indicating realistic audio synthesis.
- A CNN trained on synthetic images achieved 70.2 mean average precision on real drilling images, showing strong visual realism.
- The digital twin achieved submillimeter alignment accuracy (0.22 ± 0.03 mm) in real-world eggshell experiments.

## Abstract

To support research on autonomous robotic micro-drilling for cranial window creation in mice, a multimodal digital twin (DT) is developed to generate realistic synthetic images and drilling sounds. The realism of the DT is evaluated using data from an eggshell drilling scenario, demonstrating its potential for training AI models with multimodal synthetic data.

The asynchronous multi-body framework (AMBF) simulator for volumetric drilling with haptic feedback is combined with the Isaac Sim simulator for photorealistic rendering. A deep audio generator (DAG) model is presented and its realism is evaluated on real drilling sounds. A convolutional neural network (CNN) trained on synthetic images is used to assess visual realism by detecting drilling areas in real eggshell images. Finally, the accuracy of the DT is evaluated by experiments on a real eggshell.

The DAG model outperformed pitch modulation methods, achieving lower Frechet audio distance (FAD) and Frechet inception distance (FID) scores, demonstrating a closer resemblance to real drilling sounds. The CNN trained on synthetic images achieved a mean average precision (mAP) of 70.2 when tested on real drilling images. The DT had an alignment error of 0.22 ± 0.03 mm.

A multimodal DT has been developed to simulate the creation of the cranial window on an eggshell model and its realism has been evaluated. The results indicate a high degree of realism in both the synthetic audio and images and submillimeter accuracy.

The online version contains supplementary material available at 10.1007/s11548-025-03465-3.

## Linked entities

- **Species:** Mus musculus (taxon 10090)

## Full-text entities

- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12518470/full.md

---
Source: https://tomesphere.com/paper/PMC12518470