Influence of dual vitamin D therapy on the outcome in patients with moderate-to-severe acute anterior circulation cerebral infarction and vitamin D insufficiency

TL;DR

Dual vitamin D therapy improves recovery in stroke patients with vitamin D deficiency, without causing dangerous side effects.

Contribution

Demonstrates that dual vitamin D supplementation improves outcomes in vitamin D-deficient stroke patients.

Findings

Dual vitamin D supplementation group had more favorable 90-day mRS scores (0–3) compared to the control group.

No cases of hypercalcemia were observed in either group, indicating safety of the therapy.

Abstract

To observe whether dual vitamin D supplementation therapy can improve the prognosis of patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency.

A retrospective analysis was conducted on 36 patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency. They were divided into a dual vitamin D supplementation therapy group and a control group. The 90-day mRS scores of the two groups of patients and the occurrence of hypercalcemia were compared.

The difference in the number of mRS 0–3 cases at 90 days was statistically higher in the dual vitamin D supplementation group than in the control group (P < 0.05). No hypercalcemia was observed in either group.

Dual vitamin D supplementation improves outcomes in patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency, and is relatively safe.