Follicular Helper T Cells: Potential Interventional Targets in Atherosclerosis

TL;DR

This review explores how follicular helper T cells may play a role in atherosclerosis and could be targeted for treatment.

Contribution

The paper highlights Tfh cells as novel therapeutic targets in atherosclerosis.

Findings

Tfh cells contribute to atherosclerosis progression through abnormal cytokine and surface molecule expression.

Increased Tfh cell populations are linked to atherosclerosis and coronary artery disease.

Targeting Tfh cells and their molecules offers a promising therapeutic strategy.

Abstract

Atherosclerosis (AS) is a disease characterized by the presence of lesions in the arterial intima throughout the circulatory system. Lipid metabolism disorders form the pathological basis of AS. Immune injury resulting from lipid deposition, which is regulated by various cytokines, significantly contributes to disease progression. Follicular helper T (Tfh) cells are essential in the humoral immune response. The abnormal expression of surface molecules and cytokines by Tfh cells may contribute to the onset and progression of AS. Additionally, an increase in the Tfh cell population contributes to the progression of AS and coronary artery disease (CAD). Therefore, the targeting of Tfh cells and their associated functional molecules could serve as a promising therapeutic strategy against AS. This review summarizes current insights into the role of Tfh cells in AS and highlights their potential as therapeutic targets.

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