# The Ibogaine Experience Scale (IES): Development and psychometric properties of a multidimensional measure of ibogaine’s subjective effects

**Authors:** Francisco González Espejito, Laura Esteban Rodríguez, Eduardo J. Pedrero Pérez, Jonathan Dickinson, Maja Kohek, Rafael Guimaraes dos Santos, Jaime Hallak, Miguel Ángel Alcázar-Córcoles, Breanna Lee Morgan, José Carlos Bouso

PMC · DOI: 10.1371/journal.pone.0333296 · PLOS One · 2025-10-13

## TL;DR

Researchers created a new tool to measure the unique dream-like effects of ibogaine, a substance used in healing rituals and for treating addiction.

## Contribution

The Ibogaine Experience Scale (IES) is a novel multidimensional psychometric tool capturing ibogaine’s subjective effects.

## Key findings

- The IES comprises seven factors explaining 53.9% of variance with excellent fit indices.
- High internal consistency was observed (α = .948; ω = .946).
- Two subscales showed small gender effects.

## Abstract

Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows promise for treating opioid dependence and neurological conditions, but existing psychometric tools fail to capture its distinctive subjective/oneiric (dream-like) effects. To address this gap, we developed the 70-item Ibogaine Experience Scale (IES) through an iterative process informed by a prior qualitative study (n = 20) that identified eight experiential domains. A preliminary 144-item version was completed on site with a mobile device within 48 hours of treatment by 499 participants across two clinical settings—cohort neuropsychiatric treatments (n = 381) and substance use disorder treatments (n = 118). We employed exploratory graph analysis, parallel analysis on polychoric correlations, and iterative item‐reduction (Gulliksen’s Pool, MIREAL, MSA) to refine the scale. Semi-confirmatory factor analysis used Robust Unweighted Least Squares (RULS) with LOSEFER correction, oblimin rotation, and multiple fit indices (CFI, NNFI, GFI, AGFI, RMSR, WRMR). Cronbach’s α, McDonald’s ω, H indices, EAP reliability, FDI, ORION, SR, and EPTD assessed internal consistency and factorial quality. The final structure comprises seven factors—Narrative and symbolic visions; Visual changes; Discomfort and challenge; Cosmic/Archetypal Visions; Introspection and personal transformation; Somatosensory hypersensitivity and physiological activation; Dissociation—explaining 53.9% of variance, with excellent fit (CFI = .991; GFI = .983; RMSR = .041; WRMR = .038) and high internal consistency (α = .948; ω = .946; subscale ω = .65–.91). Two subscales exhibited small gender effects. The IES provides a reliable, phenomenologically rich instrument for quantifying ibogaine’s distinctive subjective effects. It supports research and clinical assessment by capturing the multidimensional, oneiric/dream-like nature of the ibogaine experience. Future work should confirm this structure in independent, culturally diverse cohorts and explore predictive links between IES domains and therapeutic outcomes.

## Linked entities

- **Chemicals:** ibogaine (PubChem CID 197060)
- **Diseases:** opioid dependence (MONDO:0005530)
- **Species:** Tabernanthe iboga (taxon 141617)

## Full-text entities

- **Diseases:** Somatosensory hypersensitivity (MESH:D020886), neuropsychiatric (MESH:C000631768), neurological conditions (MESH:D019636), substance use disorder (MESH:D019966), opioid dependence (MESH:D009293)
- **Chemicals:** indole alkaloid (MESH:D026121), Ibogaine (MESH:D007050)
- **Species:** Tabernanthe iboga (species) [taxon 141617]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12517489/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12517489/full.md

## References

56 references — full list in the complete paper: https://tomesphere.com/paper/PMC12517489/full.md

---
Source: https://tomesphere.com/paper/PMC12517489