# Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective

**Authors:** Kirsten Pörtner, Christina Frank, Hendrik Wilking, Klaus Stark, Christiane Herden, Martin Beer, Dennis Rubbenstroth, Dennis Tappe

PMC · DOI: 10.1371/journal.ppat.1013571 · PLOS Pathogens · 2025-10-13

## TL;DR

This paper explores whether a hypothetical vaccine could prevent fatal BoDV-1 encephalitis based on its epidemiological characteristics.

## Contribution

The paper introduces a novel epidemiological analysis of vaccination feasibility for BoDV-1 encephalitis.

## Key findings

- BoDV-1 encephalitis has a high fatality rate and lacks effective treatment.
- A hypothetical vaccine could be a viable public health strategy based on its epidemiological features.

## Abstract

Human Borna disease virus 1 (BoDV-1) encephalitis is characterized by rapid clinical progression, an absence of a causal therapy and an extremely high case fatality rate. Here, we discuss prevention options through a hypothetical vaccine focusing on epidemiological features.

## Full-text entities

- **Diseases:** encephalitis (MESH:D004660)
- **Species:** Borna disease virus 1 (no rank) [taxon 1714621]

## Full text

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## Figures

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## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12517474/full.md

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Source: https://tomesphere.com/paper/PMC12517474