# Recent Advancements in 20S Proteasome Enhancement: Degradation of Undruggable Targets

## TL;DR

This paper reviews recent progress in enhancing the 20S proteasome to target diseases like neurodegeneration.

## Contribution

The paper highlights novel developments in designing and evaluating 20S proteasome enhancers for disease treatment.

## Key findings

- Significant advancements have been made in designing potent 20S proteasome enhancers.
- These enhancers are being evaluated in disease-relevant systems for therapeutic potential.
- The ubiquitin-independent proteasome system is gaining attention for treating neurodegenerative diseases.

## Abstract

The ubiquitin-independent proteasome system has emerged
as an attractive
point of intervention for a variety of diseases, including neurodegenerative
diseases. Though inhibition of this system has been studied for decades,
20S proteasome enhancement is much younger by comparison, but substantial
levels of progress have been made in this field especially within
the last five years. This microperspective will highlight these advancements,
focusing on the novel developments being made in designing potent
enhancers and evaluating them in disease-relevant systems.