# Severe Necrotizing Anterior Scleritis in Marfan Syndrome: A Case of Scleromalacia Perforans

**Authors:** Mehrdad Motamed Shariati, Sara Ghafari

PMC · DOI: 10.1002/ccr3.71138 · 2025-10-12

## TL;DR

This paper presents a rare case of severe eye inflammation in a patient with Marfan Syndrome, highlighting the need for aggressive treatment.

## Contribution

The novelty lies in documenting scleromalacia perforans as a rare manifestation of Marfan Syndrome.

## Key findings

- Severe necrotizing anterior scleritis occurred in a patient with Marfan Syndrome.
- The condition required aggressive treatment to prevent permanent vision loss.

## Abstract

Necrotizing scleritis is considered the most severe form of scleritis. Because of the associated risk of permanent vision loss and potential complications, aggressive treatment, which may include the use of immunosuppressives or intravenous antibiotics, based on the underlying etiology, is essential.

Severe necrotizing scleritis.

## Linked entities

- **Diseases:** Marfan Syndrome (MONDO:0007947), scleromalacia perforans (MONDO:0001914), necrotizing scleritis (MONDO:0040699)

## Full-text entities

- **Diseases:** Marfan Syndrome (MESH:D008382), Scleromalacia Perforans (MESH:C536202), vision loss (MESH:D014786), Anterior Scleritis (MESH:D015423)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12515689/full.md

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Source: https://tomesphere.com/paper/PMC12515689