# The role of confocal laser endomicroscopy in pediatric gastrointestinal diseases: a narrative review

## TL;DR

This review explores how confocal laser endomicroscopy could help diagnose gastrointestinal diseases in children, though its use in pediatrics is still limited.

## Contribution

The paper consolidates current knowledge on CLE in pediatric GI diseases and suggests insights from adult studies for future research.

## Key findings

- CLE allows real-time microscopic evaluation during endoscopy.
- Applications of CLE span the entire digestive tract but remain underexplored in pediatrics.
- Few studies have investigated CLE in pediatric patients.

## Abstract

Confocal laser endomicroscopy (CLE) is an innovative tool that enables microscopic evaluation of the gastrointestinal mucosa during the digestive endoscopy, providing real-time diagnostic information alongside histopathological findings.

A literature search on CLE in pediatric gastroenterology was performed.

CLE has a broad range of applications, spanning from the upper digestive tract to the lower digestive tract, but its applications in the pediatric setting remains largely unexplored and confined to experimental setting.

Despite the extensive potential of CLE, its application in pediatric patients has been poorly investigated. This narrative review aims to consolidate the current knowledge on CLE in gastrointestinal diseases and to draw insights from adult studies to promote future research in the pediatric field.