# What Time Is It? It Is 8 and 1/2 Time: A Rare Case of Ischemic Stroke Consistent With Eight-and-a-Half Syndrome

**Authors:** Jessica Daza, Marcelo Bedoya-Sommerkamp, Eunbee Cho, Celia Daza, Francisco Gomez, Fatimah Bello, Jia Lin

PMC · DOI: 10.1177/23247096251363013 · Journal of Investigative Medicine High Impact Case Reports · 2025-08-16

## TL;DR

A 49-year-old man experienced a rare stroke syndrome affecting eye movement and facial muscles, diagnosed through imaging and treated with neurorehabilitation.

## Contribution

This paper presents a rare clinical case of eight-and-a-half syndrome caused by ischemic stroke and emphasizes the importance of accurate lesion localization for diagnosis.

## Key findings

- A subacute ischemic lesion in the right dorsal pons was identified via MRI.
- The patient showed improvement in facial palsy and ocular symptoms with treatment.
- Neurorehabilitation is recommended alongside treatment of the underlying cause.

## Abstract

Eight-and-a-half syndrome is a rare neuro-ophthalmic syndrome characterized by conjugate horizontal gaze palsy, ipsilateral internuclear ophthalmoplegia, and ipsilateral facial nerve palsy. It results from a lesion affecting the paramedian pontine reticular formation, the medial longitudinal fasciculus, and the abducens nucleus of the same side, at the level of the lower pons. We present a case of a 49-year-old man with 2-week diplopia and 3-day right-sided facial droop, drooling, and dysarthria. CT angiography of the head and neck revealed atherosclerotic disease, with decreased caliber of the basilar artery at the level of the pons. Brain MRI showed a subacute ischemic lesion in the right dorsal pons. The prognosis is favorable with improvement of facial palsy and ocular symptoms. In addition to treating the underlying etiology, neurorehabilitation is indicated. This case highlights the importance of identifying the level of the lesion in patients with gaze palsy and facial droop, as well as correlating the findings into syndromic diagnoses.

## Linked entities

- **Diseases:** ischemic stroke (MONDO:1060198)

## Full-text entities

- **Genes:** PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}
- **Diseases:** ischemic (MESH:D002545), hyperlipidemia (MESH:D006949), facial droop (MESH:D005153), Ischemic Stroke (MESH:D002544), ORCID iDs (MESH:C535742), pontine stroke (MESH:D020295), facial nerve (CN VII) palsy (MESH:D005155), neurological deficits (MESH:D009461), ischemic lesion (MESH:D017202), abduction weakness (MESH:D018908), diabetes mellitus (MESH:D003920), autoimmune (MESH:D001327), hypertension (MESH:D006973), condition (MESH:D020763), EHS (MESH:D013577), horizontal-gaze palsy (MESH:C564593), vasogenic edema (MESH:D001929), conjugate horizontal gaze palsy (MESH:D015835), ischemia (MESH:D007511), carotid stenosis (MESH:D016893), vascular lesion (MESH:D014652), neuro-ophthalmic syndrome (MESH:C535922), infarct (MESH:D007238), horizontal jerky nystagmus (MESH:D009759), hypercholesterolemia (MESH:D006937), facial palsy (MESH:D005158), Diplopia (MESH:D004172), drooling (MESH:D012798), PPRF (MESH:D058426), demyelinating conditions (MESH:D003711), gaze palsy (MESH:C565077), dysarthria (MESH:D004401), type 2 diabetes mellitus (MESH:D003924), atherosclerosis (MESH:D050197), multiple sclerosis (MESH:D009103), Hypercoagulable (MESH:D019851), peripheral facial nerve palsy (MESH:D010523), palsy (MESH:D010243), impaired ipsilateral horizontal saccades (MESH:C537423), MLF (MESH:D017887), palsy of the right eye (MESH:D005134), tuberculoma (MESH:D014375), exotropia (MESH:D005099), strokes (MESH:D020521)
- **Chemicals:** BioRender (-), sitagliptin (MESH:D000068900), aspirin (MESH:D001241), atorvastatin (MESH:D000069059), metformin (MESH:D008687), glucose (MESH:D005947), clopidogrel (MESH:D000077144), glipizide (MESH:D005913), oils (MESH:D009821), lisinopril (MESH:D017706), canagliflozin (MESH:D000068896), insulin glargine (MESH:D000069036)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12357991/full.md

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Source: https://tomesphere.com/paper/PMC12357991