# Treatment of Tuberculous Meningitis With Contezolid in a Patient With Complex Comorbidities: A Case Report and Literature Review

## TL;DR

A patient with complex health issues was successfully treated for CNS tuberculosis using contezolid, a newer antibiotic that may be safer than older alternatives.

## Contribution

This case report provides clinical evidence of contezolid's potential in treating complex CNS tuberculosis.

## Key findings

- Contezolid was part of a successful multidrug regimen for a patient with severe CNS TB and multiple comorbidities.
- The treatment suggests contezolid may be a safer alternative to linezolid in complex TB cases.
- Further research is needed to confirm the role of contezolid in CNS TB treatment.

## Abstract

Central nervous system (CNS) tuberculosis (TB) is a severe manifestation of Mycobacterium tuberculosis (MTB) infection, characterized by high mortality. Contezolid, a novel oxazolidinone antibiotic, exhibits in vitro activity against MTB and may offer a safety advantage over linezolid, a first-generation oxazolidinone frequently linked to myelosuppression and neuropathy. Clinical data on contezolid in CNS tuberculosis remain scarce. We report a middle-aged man with chronic renal allograft dysfunction who was receiving long-term hemodialysis and subsequently developed severe CNS TB complicated by multiple coinfections, diabetes mellitus, and pancytopenia. An individualized multidrug regimen that included contezolid was successfully employed, suggesting its potential utility in complex CNS TB. This report highlights therapeutic considerations for similar patients and underscores the need for further research on the role of contezolid in TB treatment.