# Effects of dexmedetomidine and magnesium sulphate on controlled hypotension in FES surgeries

## TL;DR

This study compares dexmedetomidine and magnesium sulphate for controlled hypotension during sinus surgery, finding dexmedetomidine more effective.

## Contribution

The study provides a direct comparison of two drugs for controlled hypotension in FESS, highlighting dexmedetomidine's superior efficacy.

## Key findings

- Dexmedetomidine resulted in consistently lower intraoperative mean arterial pressure than magnesium sulphate.
- Dexmedetomidine showed better performance for controlled hypotension during FESS.
- The results suggest improved surgical conditions and potential benefits for patient outcomes with dexmedetomidine.

## Abstract

Rhinosinusitis often requires functional endoscopic sinus surgery (FESS) when medical management fails, and controlled hypotension
minimizes blood loss and optimizes surgical conditions. Dexmedetomidine and magnesium sulphate are commonly used to achieve controlled
hypotension. Therefore, it is of interest to compare their efficacy in FESS, randomizing 60 patients to receive either dexmedetomidine
or magnesium sulphate. Intraoperative mean arterial pressure (MAP) was consistently lower in the dexmedetomidine group compared to the
magnesium sulphate group (p<0.01). We show that dexmedetomidine demonstrated superior performance for controlled hypotension during
FESS, potentially improving surgical conditions and patient outcomes.