# Clinical and cost-effectiveness of synbiotics versus antibiotics and analgesics in post-tooth extraction socket healing: A randomized controlled trial

**Authors:** Heena Shaikh, Lata Ajay Tapnikar, Vidyalakshmi Shankararaman, Shrikant Patel, Dhrumi Shah, Vyoma Patel

PMC · DOI: 10.6026/973206300211719 · Bioinformation · 2025-05-31

## TL;DR

This study compares synbiotics to antibiotics and analgesics for healing after tooth extraction, finding synbiotics more effective.

## Contribution

The study introduces synbiotics as a novel alternative to antibiotics and analgesics for post-extraction healing.

## Key findings

- Group 1 (synbiotics) had the lowest bleeding, discomfort, and swelling.
- Group 3 (antibiotics and analgesics) showed the highest levels of complications.
- Synbiotics appear to promote better post-extraction wound healing.

## Abstract

There has been a noticeable increase in the use of alternative strategies such as herbal medicines and laser therapies to tackle a
range of health issues, including oral diseases. Therefore, it is of interest to examine how synbiotics affect tooth extraction socket
healing and problems. Hence, a total of 210 patients, were split into three groups of 70 individuals each. The primary outcome measures
were assessed on the 3rd, 5th, and 7th days after the extraction. Group 3 patients had the highest incidence of bleeding, while group 1
had the lowest. Group 3 experienced the highest level of discomfort and swelling, while group 1 reported the lowest. Thus,
post-extraction wound healing using synbiotics' benefits.

## Full-text entities

- **Diseases:** oral diseases (MESH:D009059), swelling (MESH:D004487), bleeding (MESH:D006470)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12357718/full.md

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Source: https://tomesphere.com/paper/PMC12357718