# Comparative study of epidural ropivacaine and bupivacaine with fentanyl in abdominal surgery

**Authors:** Asif Kalas, Meghana P Rao, Anwar Hussain

PMC · DOI: 10.6026/973206300211739 · Bioinformation · 2025-05-31

## TL;DR

This study compares the effectiveness of ropivacaine and bupivacaine with fentanyl for pain relief after abdominal surgery.

## Contribution

The study demonstrates that ropivacaine and bupivacaine can be used interchangeably for epidural analgesia in abdominal surgery.

## Key findings

- Both ropivacaine and bupivacaine with fentanyl provided similar sensory and motor block characteristics.
- Patients in both groups had comparable pain scores and stable hemodynamics over 24 hours.
- No major complications were observed in either group.

## Abstract

The efficacy of equal doses of ropivacaine and bupivacaine with fentanyl as continuous epidural infusions for postoperative analgesia
in abdominal surgeries is of interest. Sixty patients were randomized into two groups receiving either ropivacaine or bupivacaine with
fentanyl intra-operatively and postoperatively. Sensory and motor blocks, hemodynamic parameters, and pain scores were monitored for 24
hours after surgery. Both groups showed similar sensory and motor block characteristics and recovery profiles with comparable drug
dosages. We conclude that ropivacaine and bupivacaine can be used interchangeably as epidural infusions for effective postoperative
analgesia with stable hemodynamic and no major complications.

## Linked entities

- **Chemicals:** ropivacaine (PubChem CID 71273), bupivacaine (PubChem CID 2474), fentanyl (PubChem CID 3345)

## Full-text entities

- **Diseases:** pain (MESH:D010146), sensory and motor block (MESH:D006327)
- **Chemicals:** bupivacaine (MESH:D002045), fentanyl (MESH:D005283), ropivacaine (MESH:D000077212)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12357713/full.md

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Source: https://tomesphere.com/paper/PMC12357713