# Perio-dontal - Neuro-immune axis: Expression analysis of Vitamin D and brain-derived neurotrophic factor in periodontitis patients with neuro-psychiatric disorders

## TL;DR

This study explores the connection between periodontal disease, mental health, and vitamin D and BDNF levels in saliva.

## Contribution

The study identifies a potential link between periodontitis and neuropsychiatric disorders through salivary biomarkers.

## Key findings

- Patients with periodontitis and neuropsychiatric disorders had lower Vitamin D and BDNF levels.
- These patients also showed higher BMI and worse periodontal indicators.
- No direct correlation was found between biochemical markers and periodontal parameters.

## Abstract

The association between periodontal health, neuropsychiatric status and metabolic indicators by assessing salivary Vitamin D and
brain-derived neurotrophic factor (BDNF) levels is of interest. Eighty participants were categorized into four groups based on
periodontal and neuropsychiatric status. Patients with both periodontitis and neuropsychiatric disorders showed significantly higher
age, BMI, plaque index and probing depth and lower Vitamin D, BDNF levels and mental health scores (p < 0.001). No significant
correlation was observed between biochemical markers and periodontal parameters. The findings suggest a potential link between
periodontal inflammation and neuropsychiatric conditions, emphasizing the relevance of multidisciplinary care.