# Management of intra-bony defects using nano HA+PRF over its combination with a diode laser

**Authors:** Saurabh Gupta, Pravin M. Parmar, Ravinder Singh, Nitika Gupta, Lubna Tabassum Siddiqui, Shahbaz Asif Ali, Shail D. Kushwaha, Abhigyan Manas

PMC · DOI: 10.6026/973206300211108 · Bioinformation · 2025-05-31

## TL;DR

This study compares the effectiveness of using nano HA+PRF with or without a diode laser for healing intra-bony defects in periodontitis patients.

## Contribution

The study introduces the combination of a diode laser with nano HA+PRF for managing intra-bony defects.

## Key findings

- Both groups showed significant reductions in plaque index, probing depth, gingival index, gingival recession, and root coverage after six months.
- Intra-bony pockets were significantly reduced in both the control and test groups.

## Abstract

Patients with periodontitis frequently have intra-bony defects. Therefore, it is of interest to evaluate the use of a diode laser and
a bone graft (nano hydroxyapatite [HA] + platelet rich fibrin [PRF]) in healing of intra-bony defects. In this split-mouth evaluation,
20 patients with bilateral intra-bony defects were divided into 2 groups as; Group I (control) - nano HA + PRF and Group II (Test
group)--bone graft (nano HA + PRF)+ diode laser and treated accordingly. After six months, reductions in PI, PD, GI, GR, and RCAL were
discovered. Intra-bony pockets were found to have significantly decreased in both groups.

## Linked entities

- **Diseases:** periodontitis (MONDO:0005076)

## Full-text entities

- **Genes:** RCN1 (reticulocalbin 1) [NCBI Gene 5954] {aka HEL-S-84, PIG20, RCAL, RCN}
- **Diseases:** Intra (MESH:D057072), periodontitis (MESH:D010518), bony (MESH:D018213)
- **Chemicals:** hydroxyapatite (MESH:D017886)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12357686/full.md

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Source: https://tomesphere.com/paper/PMC12357686