# Hemodynamic stability with clonidine versus adrenaline in mandibular third molar surgeries

## TL;DR

This study compares clonidine and adrenaline in dental surgery anesthesia, finding clonidine better for maintaining stable blood pressure and heart rate.

## Contribution

The study provides empirical evidence that clonidine is safer for hemodynamic stability in third molar surgeries compared to adrenaline.

## Key findings

- Clonidine resulted in lower systolic, diastolic blood pressure, heart rate, and mean arterial pressure during and after surgery.
- Clonidine provided superior hemodynamic control despite a slightly slower onset of anesthesia.
- Clonidine is suggested as a safer alternative for patients needing cardiovascular stability.

## Abstract

This randomized clinical trial compares 2% lignocaine with clonidine versus 2% lignocaine with adrenaline for impacted mandibular
third molar surgery. Hence, 70 patients aged 18-40 were randomly allocated to either group. We evaluated hemodynamic stability, onset
and duration of anesthesia. Clonidine showed lower intraoperative and postoperative systolic blood pressure (SBP), diastolic blood
pressure (DBP), heart rate (HR) and mean arterial pressure (MAP). Though onset was slightly slower with clonidine, hemodynamic control
was superior. Clonidine appears to be a safer alternative for patients requiring cardiovascular stability.