# Periapical healing in endodontic retreatment: A comparative study of nano-hydroxyapatite with and without PRF

## TL;DR

This study compares nano-hydroxyapatite with and without PRF for healing after dental retreatment, finding faster initial healing with the combination.

## Contribution

The study introduces a novel combination of nano-hydroxyapatite and PRF for periapical healing in endodontic retreatment.

## Key findings

- Both groups showed significant lesion size reduction over time.
- The nHA+PRF group exhibited faster healing at the 1-month follow-up.
- No long-term differences were observed between the groups.

## Abstract

The efficacy of nano-hydroxyapatite (nHA) alone and in combination with platelet-rich fibrin (PRF) in enhancing periapical bone
healing following endodontic retreatment is of interest. Thirty-two patients with failed endodontic treatment in anterior teeth were
divided into two groups. After retreatment, apicoectomy and root-end filling with mineral trioxide aggregate (MTA) were performed. Group
1 received nHA alone, while Group 2 received a combination of nHA and PRF in the periapical cavity. Follow-ups at 1, 3, and 6 months
showed significant lesion size reduction in both groups, with faster healing in the nHA+PRF group at 1 month, but no long-term
differences.