# Assessment of peri-neural invasion in oral cancer patients using MRI: A clinical and radiologic correlation study

**Authors:** Diksha Koushal, Shaivi Sharma, Cheena Singh, Mangala Sajjanar, Prachi Nayak, Swapna Munga, Arpita Saha

PMC · DOI: 10.6026/973206300211118 · Bioinformation · 2025-05-31

## TL;DR

This study shows MRI is reliable for detecting perineural invasion in oral cancer, matching results from tissue analysis.

## Contribution

The study demonstrates MRI's reliability in detecting perineural invasion in oral cancer patients compared to histopathology.

## Key findings

- MRI shows strong agreement with histopathology in detecting perineural invasion in oral cancer.
- MRI is a reliable diagnostic tool for perineural invasion in oral squamous cell carcinoma.
- Further validation in larger populations is recommended.

## Abstract

The diagnostic concordance between MRI and histopathology for detecting perineural invasion (PNI) in Oral squamous cell carcinoma
(OSCC) patients is of interest. A cross-sectional analytical study was conducted involving 140 patients with histopathologically
confirmed OSCC. Demographic, clinical and MRI data were collected, focusing on the presence of PNI, which was compared with
histopathological findings for diagnostic accuracy. MRI is a reliable diagnostic tool for detecting perineural invasion in OSCC, with
strong agreement to histopathological findings, supporting its clinical utility in treatment planning. Further studies are warranted to
validate these findings across larger populations.

## Linked entities

- **Diseases:** Oral squamous cell carcinoma (MONDO:0004958)

## Full-text entities

- **Diseases:** OSCC (MESH:D000077195), oral cancer (MESH:D009062)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12357655/full.md

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Source: https://tomesphere.com/paper/PMC12357655