# Effect of progesterone sequential therapy on follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) in perimenopausal dysfunctional uterine bleeding

## TL;DR

This study examines how progesterone sequential therapy affects hormone levels in women with perimenopausal dysfunctional uterine bleeding.

## Contribution

The study introduces progesterone sequential therapy as a treatment for PDUB and evaluates its impact on key reproductive hormones.

## Key findings

- FPST significantly reduced FSH and LH levels in PDUB patients.
- Estradiol levels were also notably decreased in the FPST group.
- FPST showed better clinical outcomes compared to curettage alone.

## Abstract

Perimenopausal dysfunctional uterine bleeding (PDUB) is a common gynaecological disease with various clinical treatment options. The objective of this work was to investigate the clinical effect of female progesterone sequential therapy (FPST) on PDUB and follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2).

140 cases of PDUB patients were enrolled and randomly rolled into an observation (Obs) group and a control (Ctrl) group, with 70 cases in each. The patients in the Ctrl group were given pure curettage treatment, and those in the Obs group were supplemented with FPST based on the intervention in the Ctrl group.