# Biochemical impact and therapeutic efficacy of laparoscopic surgery in early-stage ovarian cancer: Modulation of vascular endothelial growth factor and tumor markers

## TL;DR

This study compares laparoscopic and open surgery in early ovarian cancer, finding that laparoscopic surgery reduces tumor markers and improves survival without more complications.

## Contribution

The study demonstrates that laparoscopic surgery modulates angiogenesis and tumor markers more effectively than open surgery in early-stage ovarian cancer.

## Key findings

- Laparoscopic surgery led to significantly lower postoperative VEGF, MMP9, SDF-1a, and CEA levels compared to open surgery.
- The 24-month survival rate was higher in the laparoscopic group without increased complications.
- Laparoscopic surgery reduced intraoperative blood loss and improved recovery times compared to open surgery.

## Abstract

The objective of this study was to investigate the biochemical impact of laparoscopic surgery on angiogenesis, focusing on vascular endothelial growth factor (VEGF), and the modulation of key tumor markers in patients with early-stage ovarian cancer.

A total of 76 patients diagnosed with early ovarian cancer were enrolled and divided into two groups based on the surgical approach: the control group (n=38) underwent open surgery, and the observation group (n=38) underwent laparoscopic surgery. Surgical parameters, VEGF levels, tumor markers [matrix metalloproteinase 9 (MMP9), stromal cell-derived factor-1a (SDF-1a), and carcinoembryonic antigen (CEA)], survival rates, and incidence of complications were compared between the two groups.

The duration of surgery was longer in the observation group than in the control group. However, the hospitalization time, recovery of bowel function, and length of surgical incision were significantly shorter in the observation group. Intraoperative blood loss was also significantly lower in the observation group, with all differences being statistically significant (P<0.01). Seven days post-surgery, VEGF, MMP9, SDF-1a, and CEA levels in both groups decreased compared to their preoperative levels. These levels were significantly lower in the observation group than in the control group (P<0.05). The 24-month survival rate was higher in the observation group (P<0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P>0.05).

Laparoscopic surgery for early ovarian cancer results in minimal trauma, reduces VEGF and tumor marker levels, and improves the 24-month survival rate without increasing the incidence of complications.