Unicentric Hyaline-Vascular Castleman Disease Presenting as a Periduodenal Mass: A Rare Retroperitoneal Manifestation

TL;DR

A rare case of Castleman disease is reported as a mass near the duodenum, emphasizing the need to consider this condition in unusual retroperitoneal locations.

Contribution

The paper presents a rare retroperitoneal manifestation of unicentric hyaline-vascular Castleman disease near the duodenum.

Findings

A 46-year-old male was diagnosed with unicentric hyaline-vascular Castleman disease via biopsy and surgical resection.

The disease presented as a retroperitoneal mass posterior to the duodenum, an atypical location for Castleman disease.

The case underscores the importance of including Castleman disease in the differential diagnosis of retroperitoneal masses.

Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder, typically presenting in the mediastinum. We report a case of a 46-year-old male with back and abdominal pain found to have an incidental 3.9 cm retroperitoneal mass posterior to the duodenum. Endoscopic biopsy revealed atypical B-cell proliferation, and surgical resection confirmed unicentric hyaline-vascular CD. This case highlights a rare periduodenal presentation and underscores the importance of including CD in the differential diagnosis of retroperitoneal masses, even in atypical locations, to ensure timely recognition and management.

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