# Genetic structure of Bithynia snails and its implications for targeted control of opisthorchiasis in the Lower Mekong Subregion

**Authors:** Nathkapach Kaewpitoon Rattanapitoon, Chutharat Thanchonnang, Schawanya Kaewpitoon Rattanapitoon

PMC · DOI: 10.1186/s41182-025-00774-w · 2025-08-15

## TL;DR

This paper discusses how the genetic diversity of snails affects the spread of a liver disease in Southeast Asia and suggests better control strategies.

## Contribution

The paper introduces the use of snail genetic lineages to improve targeted control of opisthorchiasis in the Lower Mekong Subregion.

## Key findings

- Distinct mitochondrial lineages of Bithynia snails were identified in Champasak, Laos.
- Lineage II shows high haplotype diversity and habitat-specific distribution.
- Genetic monitoring of snails could improve liver fluke elimination strategies.

## Abstract

Recent findings by Bunchom et al. reveal distinct mitochondrial lineages of Bithynia siamensis goniomphalos in Champasak, Laos, with important implications for Opisthorchis viverrini transmission. The identification of lineage II, with high haplotype diversity and habitat-specific distribution, underscores the role of snail genetics in shaping local disease dynamics. Drawing parallels from Thailand’s successful One Health intervention, this correspondence advocates for integrating lineage-informed mapping and surveillance into regional control programs. Broader genetic monitoring of Bithynia snails across the Lower Mekong Subregion may enhance the precision and effectiveness of liver fluke elimination strategies.

## Linked entities

- **Diseases:** opisthorchiasis (MONDO:0005884)
- **Species:** Opisthorchis viverrini (taxon 6198)

## Full-text entities

- **Diseases:** liver fluke (MESH:D017093), O. viverrini infection (MESH:D009889)
- **Species:** Bithynia siamensis goniomphalos [taxon 479249], Homo sapiens (human, species) [taxon 9606], Opisthorchis viverrini (Southeast Asian liver fluke, species) [taxon 6198], Bithynia funiculata (species) [taxon 479247], Bithynia siamensis (species) [taxon 479248]

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Source: https://tomesphere.com/paper/PMC12355789