Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
Wugang Zhu, Wenjing Xu, Degan Liu, Lei Wan, Xiaolan Lu
TL;DR
This study finds that combining immunotherapy with chemotherapy improves survival and effectiveness in non-small cell lung cancer without increasing severe side effects.
Contribution
The novel contribution is a meta-analysis showing combination therapy improves survival and response rates without more adverse effects.
Findings
Combination treatment improved 1-year survival, response rate, and disease control compared to chemotherapy alone.
No significant increase in adverse reactions was observed with the combination therapy.
Immune markers CD4+ and CD4+/CD8+ were higher in the combination group.
Abstract
This study aimed to assess the clinical effectiveness and safety of combining immunotherapy with chemotherapy for non-small cell lung cancer. A comprehensive search of studies published until January 2024 was conducted. Quality assessment was performed using the NOS scale, and a meta-analysis was carried out with RevMan 5.4.1 software. Heterogeneity was assessed using the Q-test, and combined effects were calculated with fixed or random effects models. Results were visualized using forest plots, and a sensitivity analysis was performed. Out of 1,061 sources, 11 met the inclusion criteria. The meta-analysis indicated that the combination treatment significantly improved 1-year overall survival, objective response rate, and disease control rate compared to chemotherapy alone (P < 0.05), with no significant difference in adverse reactions (P > 0.05). Immune function markers CD4+ and…
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Taxonomy
TopicsCancer Immunotherapy and Biomarkers · Immunotherapy and Immune Responses · Lung Cancer Research Studies