# A novel hybrid genetic algorithm and Nelder-Mead approach and it’s application for parameter estimation

**Authors:** Neha Majhi, Rajashree Mishra, Olympia Roeva, Rajashree Mishra, El-ghalia Boudissa, HABBI FATIHA, Rajashree Mishra

PMC · DOI: 10.12688/f1000research.154598.1 · 2024-09-19

## TL;DR

This paper introduces GANMA, a new hybrid optimization method combining genetic algorithms and Nelder-Mead for better performance in solving complex optimization and parameter estimation problems.

## Contribution

The novel hybrid Genetic and Nelder-Mead Algorithm (GANMA) is proposed for improved optimization and parameter estimation.

## Key findings

- GANMA outperforms traditional methods in robustness, convergence speed, and solution quality.
- The algorithm excels in high-dimensional and multimodal function landscapes.
- GANMA improves model accuracy and interpretability in parameter estimation tasks.

## Abstract

Traditional optimization methods often struggle to balance global exploration and local refinement, particularly in complex real-world problems. To address this challenge, we introduce a novel hybrid optimization strategy that integrates the Nelder-Mead (NM) technique and the Genetic Algorithm (GA), named the Genetic and Nelder-Mead Algorithm (GANMA). This hybrid approach aims to enhance performance across various benchmark functions and parameter estimation tasks.

GANMA combines the global search capabilities of GA with the local refinement strength of NM. It is first tested on 15 benchmark functions commonly used to evaluate optimization strategies. The effectiveness of GANMA is also demonstrated through its application to parameter estimation problems, showcasing its practical utility in real-world scenarios.

GANMA outperforms traditional optimization methods in terms of robustness, convergence speed, and solution quality. The hybrid algorithm excels across different function landscapes, including those with high dimensionality and multimodality, which are often encountered in real-world optimization issues. Additionally, GANMA improves model accuracy and interpretability in parameter estimation tasks, enhancing both model fitting and prediction.

GANMA proves to be a flexible and powerful optimization method suitable for both benchmark optimization and real-world parameter estimation challenges. Its capability to efficiently explore parameter spaces and refine solutions makes it a promising tool for scientific, engineering, and economic applications. GANMA offers a valuable solution for improving model performance and effectively handling complex optimization problems.

## Full-text entities

- **Diseases:** GA (MESH:D030342), NMA (MESH:D007859)
- **Chemicals:** GA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

20 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12355169/full.md

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Source: https://tomesphere.com/paper/PMC12355169