Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma
Liang Chu, Han Wang, Tao Ling, Shuhan Feng, Yucheng Ding, Yan Zhang, Ying Pan, Cenzhu Wang, Xiaohong Wang, Lei Liu
TL;DR
This study shows that combining lymph node ratio, tumor deposits, and perineural invasion improves survival prediction in advanced colorectal signet-ring cell carcinoma.
Contribution
The combined analysis of LNR, TD, and PNI provides higher prognostic value than traditional staging factors in advanced SRCC.
Findings
High LNR, TD-positive, and PNI-positive were linked to worse cancer-specific and overall survival.
A nomogram model incorporating LNR, TD, and PNI showed excellent predictive accuracy and calibration.
The combined variable of LNR, TD, and PNI contributed more to survival prediction than T and M stages.
Abstract
The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC). A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models. A nomogram model was developed to predict outcomes. High-LNR, TD-positive, and PNI-positive were associated with poorer CSS and OS in both the training and validation cohorts. Multivariate Cox analysis identified T stage, M stage, TD, CEA, chemotherapy, and LNR as independent prognostic factors. A prognostic nomogram model incorporating these variables demonstrated excellent calibration and satisfactory predictive accuracy.…
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Taxonomy
TopicsColorectal Cancer Surgical Treatments · Colorectal and Anal Carcinomas · Gastric Cancer Management and Outcomes