# Unexpected Stroke Two Years After Atrial Septal Defect Closure: A Case of Late Device Embolization

**Authors:** Nuria Pueyo‐Balsells, Ignacio Barriuso, Marta Zielonka, Carlos Izurieta, Kristian Rivera

PMC · DOI: 10.1002/ccr3.70718 · 2025-08-14

## TL;DR

A woman experienced a stroke two years after heart defect closure due to device embolization, highlighting the need for long-term monitoring.

## Contribution

This case highlights inherited thrombophilia's role in embolic events and the importance of long-term surveillance after device implantation.

## Key findings

- Device embolization occurred two years after ASD closure, causing an ischemic stroke.
- Conservative management was successful despite device migration.
- Multimodal imaging was crucial for diagnosis and guiding treatment decisions.

## Abstract

A 42‐year‐old woman with a C677T mutation in the methylenetetrahydrofolate reductase gene and a history of transient ischemic attack underwent transcatheter closure of an ostium secundum atrial septal defect (ASD‐OS) using a Figulla Flex II device. Two years later, she presented with an ischemic stroke. Imaging revealed late embolization of the occluder device to the aorto‐iliac bifurcation. As she remained asymptomatic, a conservative approach was adopted. A second transcatheter ASD‐OS closure was successfully performed. This case underscores the potential contribution of inherited thrombophilia to recurrent embolic events, the importance of long‐term surveillance for device complications, and the value of multimodal imaging in guiding clinical decision making.

## Linked entities

- **Genes:** MTHFR (methylenetetrahydrofolate reductase) [NCBI Gene 4524]
- **Diseases:** ischemic stroke (MONDO:1060198), transient ischemic attack (MONDO:0005264), atrial septal defect (MONDO:0006664)

## Full-text entities

- **Genes:** MTHFR (methylenetetrahydrofolate reductase) [NCBI Gene 4524]
- **Diseases:** ASD-OS (MESH:C567932), ischemic attack (MESH:D002546), ischemic stroke (MESH:D002544), Stroke (MESH:D020521), Atrial Septal Defect Closure (MESH:D006344), embolic events (MESH:D004617), inherited thrombophilia (MESH:C540694)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** C677T

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12354973/full.md

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Source: https://tomesphere.com/paper/PMC12354973