# Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases **Authors:** Yang Li, Wenying Zhang, Bo Wang, Fuju Wu PMC · DOI: 10.1007/s13577-025-01268-x · Human Cell · 2025-08-14 ## TL;DR This review explores how the DNA repair enzyme OGG1 contributes to inflammation and cell death in reproductive diseases, suggesting it could be a new therapeutic target. ## Contribution The paper provides a comprehensive review of OGG1's non-canonical roles in obstetric and gynecological diseases. ## Key findings - OGG1 influences inflammation and cell death pathways relevant to reproductive disorders. - OGG1 may play a role in conditions like endometriosis and polycystic ovary syndrome. - The enzyme shows promise as a potential therapeutic target for these diseases. ## Abstract The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including 7,8-dihydro-8-oxoguanine (8-oxoG). Beyond its canonical function in DNA repair, OGG1 has been implicated in regulating inflammation-related genes, growth factor expression, and various cell death pathways, including apoptosis, parthanatos, and autophagy. These mechanisms are often involved in obstetric and gynecological disorders, which are frequently characterized by inflammation, endothelial dysfunction, and dysregulated cell death. As such, OGG1 emerges as a potential therapeutic target for these conditions. However, comprehensive reviews detailing OGG1’s mechanistic roles in reproductive diseases remain scarce. This review aims to synthesize current knowledge primarily on non-canonical functions of OGG1, with a focus on its potential involvement in disorders such as endometriosis, polycystic ovary syndrome, uterine fibroids, and malignancies, and to highlight its promise as a therapeutic target. ## Linked entities - **Genes:** OGG1 (8-oxoguanine DNA glycosylase) [NCBI Gene 4968] - **Chemicals:** 7,8-dihydro-8-oxoguanine (PubChem CID 135420630) - **Diseases:** endometriosis (MONDO:0005133), polycystic ovary syndrome (MONDO:0008487) ## Full-text entities - **Genes:** TLR7 (toll like receptor 7) [NCBI Gene 51284] {aka IMD74, SLEB17, TLR7-like}, CYP4F3 (cytochrome P450 family 4 subfamily F member 3) [NCBI Gene 4051] {aka CPF3, CYP4F, CYPIVF3, LTB4H}, TLR9 (toll like receptor 9) [NCBI Gene 54106] {aka CD289}, Cgas (cyclic GMP-AMP synthase) [NCBI Gene 214763] {aka E330016A19Rik, Mb21d1}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, SIRT3 (sirtuin 3) [NCBI Gene 23410] {aka SIR2L3}, Sting1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 72512] {aka 2610307O08Rik, ERIS, MPYS, Mita, STING, STING-beta}, RHOG (ras homolog family member G) [NCBI Gene 391] {aka ARHG}, CD83 (CD83 molecule) [NCBI Gene 9308] {aka BL11, HB15}, APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1) [NCBI Gene 328] {aka APE, APE1, APEN, APEX, APX, HAP1}, OGG1 (8-oxoguanine DNA glycosylase) [NCBI Gene 4968] {aka HMMH, HOGG1, MUTM, OGH1}, Stat1 (signal transducer and activator of transcription 1) [NCBI Gene 20846] {aka 2010005J02Rik}, MUTYH (mutY DNA glycosylase) [NCBI Gene 4595] {aka MYH}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, HRAS (HRas proto-oncogene, GTPase) [NCBI Gene 3265] {aka C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, MYD88 (MYD88 innate immune signal transduction adaptor) [NCBI Gene 4615] {aka IMD68, MYD88D, WM1}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, CD40 (CD40 molecule) [NCBI Gene 958] {aka Bp50, CDW40, TNFRSF5, p50}, IGHE (immunoglobulin heavy constant epsilon) [NCBI Gene 3497] {aka IgE}, MAP1LC3A (microtubule associated protein 1 light chain 3 alpha) [NCBI Gene 84557] {aka ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3}, PINK1 (PTEN induced kinase 1) [NCBI Gene 65018] {aka BRPK, PARK6}, CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 3576] {aka GCP-1, GCP1, IL8, LECT, LUCT, LYNAP}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, IFNB1 (interferon beta 1) [NCBI Gene 3456] {aka IFB, IFF, IFN-beta, IFNB}, PRKN (parkin RBR E3 ubiquitin protein ligase) [NCBI Gene 5071] {aka AR-JP, LPRS2, PARK2, PDJ}, NRAS (NRAS proto-oncogene, GTPase) [NCBI Gene 4893] {aka ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6}, Irf9 (interferon regulatory factor 9) [NCBI Gene 16391] {aka Irf-9, Isgf3g, p48}, Isg15 (ISG15 ubiquitin-like modifier) [NCBI Gene 100038882] {aka G1p2, IGI15, IP17, Irfp, UCRP}, Ifnb1 (interferon beta 1, fibroblast) [NCBI Gene 15977] {aka IFN-beta, IFNB, If1da1, Ifb}, CD86 (CD86 molecule) [NCBI Gene 942] {aka B7-2, B7.2, B70, BU63, CD28LG2, CD86 v6}, ATG7 (autophagy related 7) [NCBI Gene 10533] {aka APG7-LIKE, APG7L, GSA7, SCAR31}, PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2) [NCBI Gene 5563] {aka AMPK, AMPK2, AMPKa2, PRKAA}, Sp1 (trans-acting transcription factor 1) [NCBI Gene 20683] {aka 1110003E12Rik, Sp1-1}, NUDT1 (nudix hydrolase 1) [NCBI Gene 4521] {aka MTH1}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, Rela (Rela proto-oncogene, NFKB subunit) [NCBI Gene 19697] {aka p65, p65 NF-kappa B, p65 NFkB}, ACO2 (aconitase 2) [NCBI Gene 50] {aka ACONM, HEL-S-284, ICRD, OCA8, OPA9}, AIFM1 (apoptosis inducing factor mitochondria associated 1) [NCBI Gene 9131] {aka AIF, AUNX1, CMT2D, CMTX4, COWCK, COXPD6}, RAC1 (Rac family small GTPase 1) [NCBI Gene 5879] {aka MIG5, MRD48, Rac-1, TC-25, p21-Rac1}, HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}, H3P16 (H3 histone pseudogene 16) [NCBI Gene 644914] {aka H3.6, H3F3AP6, p21}, PARP1 (poly(ADP-ribose) polymerase 1) [NCBI Gene 142] {aka ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, BECN1 (beclin 1) [NCBI Gene 8678] {aka ATG6, VPS30, beclin1}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, Serpinb1-ps1 (serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene) [NCBI Gene 282665] {aka EID, ovalbumin}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) [NCBI Gene 18033] {aka NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105}, IL23A (interleukin 23 subunit alpha) [NCBI Gene 51561] {aka IL-23, IL-23A, IL23P19, P19, SGRF}, Ogg1 (8-oxoguanine DNA-glycosylase 1) [NCBI Gene 18294] {aka Mmh} - **Diseases:** preterm labor (MESH:D007752), lung fibrosis (MESH:D005355), ovarian and cervical cancer (MESH:D010051), premature rupture of fetal membranes (MESH:D005322), term (MESH:D000088562), obstetric and gynecologic malignancies (MESH:D005833), Parkinson's disease (MESH:D010300), pathological ovary syndrome (MESH:D016649), Cancer (MESH:D009369), diabetes (MESH:D003920), preterm birth (MESH:D047928), carcinogenesis (MESH:D063646), uterine fibroids (MESH:D007889), autoimmune disorders (MESH:D001327), tissue (MESH:D017695), reproductive endocrine disorder (MESH:D004700), reproductive diseases (MESH:D060737), renal ischemia (MESH:D007511), endothelial dysfunction (MESH:D014652), Preeclampsia (MESH:D011225), asthma (MESH:D001249), Obstetric and gynecological diseases (MESH:D005831), cardiovascular disease (MESH:D002318), pulmonary fibrosis (MESH:D011658), PCOS (MESH:D011085), cervical cancer (MESH:D002583), metabolic abnormalities (MESH:D008659), recurrent miscarriage (MESH:D000026), reperfusion injury (MESH:D015427), neuronal loss (MESH:D009410), eclampsia (MESH:D004461), hypoxia (MESH:D000860), allergic airway inflammation (MESH:D007249), lung cancer (MESH:D008175), breast carcinogenesis (MESH:D061325), mitochondrial dysfunction (MESH:D028361), Endometriosis (MESH:D004715), diseases (MESH:D004194), degenerative diseases (MESH:D019636), stroke (MESH:D020521) - **Chemicals:** oligodeoxynucleotides (MESH:D009838), 8-oxo-7,8-dihydroadenine (MESH:C000626543), butylated hydroxyanisole (MESH:D002083), TH5487 (MESH:C000712208), 8-OHdG (MESH:D000080242), ONOO- (-), lipids (MESH:D008055), rapamycin (MESH:D020123), H2O2 (MESH:D006861), progesterone (MESH:D011374), free radicals (MESH:D005609), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (MESH:C071023), E2 (MESH:D004958), GTP (MESH:D006160), nucleotides (MESH:D009711), vitamin C (MESH:D001205), O -2 (MESH:D013481), guanine (MESH:D006147), 8-oxoG (MESH:C024829), OH (MESH:C031356), cytosine (MESH:D003596), lipid peroxides (MESH:D008054), adenine (MESH:D000225), peroxynitrite (MESH:D030421), guanosine (MESH:D006151), ROS (MESH:D017382), GDP (MESH:D006153), 7,8-dihydro-8-oxoguanine (MESH:C453560), biotin (MESH:D001710), ATP (MESH:D000255), hydroxyl radicals (MESH:D017665) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116] - **Mutations:** serine/threonine, Ser326Cys, adenine instead of cytosine ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12354143/full.md ## Figures 4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12354143/full.md --- Source: https://tomesphere.com/paper/PMC12354143