# Techno‐economic analysis of membrane‐based continuous capture chromatography platforms for large‐scale antibody production

## TL;DR

This paper analyzes membrane-based continuous capture chromatography platforms for producing monoclonal antibodies, showing they can reduce costs and improve efficiency compared to traditional methods.

## Contribution

The study introduces a simulation and optimization framework for techno-economic analysis of continuous antibody production platforms.

## Key findings

- Membrane continuous platforms showed lower cost of goods and process mass intensity compared to resin-based alternatives.
- Shorter residence times in membrane platforms make them more flexible for varying throughput and integration into continuous processes.
- Optimal configurations revealed performance differences due to dynamic binding capacity, media geometry, and process residence time.

## Abstract

Continuous manufacturing platforms and membrane chromatography are process technologies with the potential to reduce production costs and minimize process variability in monoclonal antibody production. This study presents a simulation and optimization framework to perform techno‐economic analyses of these strategies. Multi‐objective optimization was used to compare batch and continuous multicolumn operating modes and membrane and resin process alternatives, revealing performance differences in productivity and cost of goods attributed to variations in dynamic binding capacity, media geometry, and process residence time. From the set of optimal process configurations, we selected one membrane and one resin platform alternative yielding the highest net present values to undergo sensitivity analyses involving variations in batch cadence and product selling price. For the scenarios considered in this work, membrane continuous platforms showed benefits in the cost of goods and process mass intensity. Their shorter residence time compared to resins positions them as a viable alternative for single‐use capture chromatography. Moreover, this low residence time makes membrane platforms more flexible to changes in throughput, an essential feature for integrating capture into fully continuous processes.