This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsEicosanoids and Hypertension Pharmacology · Cancer, Hypoxia, and Metabolism · ATP Synthase and ATPases Research
After the publication of this article [1], concerns were raised with results presented in Fig 4. Specifically,
In addition to the issues listed above, concerns were raised about the validity of primers used in the RT-PRC experiment.
The authors did not respond to the journal’s communications, and the concerns remain unresolved.
The unresolved concerns call into question the reliability and validity of the published results, and the article’s adherence to the journal’s editorial policies in place at the time the article was submitted. In light of these unresolved concerns, the PLOS One Editors retract this article.
All authors either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Raghu H, Lakka SS, Gondi CS, Mohanam S, Dinh DH, Gujrati M, et al. Suppression of u PA and u PAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines. P Lo S One. 2010;5(8):e 12458. doi: 10.1371/journal.pone.0012458 20805979 PMC 2929192 · doi ↗ · pubmed ↗
- 2Raghu H, Gondi CS, Dinh DH, Gujrati M, Rao JS. Specific knockdown of u PA/u PAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor. Mol Cancer. 2011;10:130. doi: 10.1186/1476-4598-10-130 22004682 PMC 3210098 · doi ↗ · pubmed ↗
- 3Allen M, Bjerke M, Edlund H, Nelander S, Westermark B. Origin of the U 87MG glioma cell line: Good news and bad news. Sci Transl Med. 2016;8(354):354re 3. doi: 10.1126/scitranslmed.aaf 6853 27582061 · doi ↗ · pubmed ↗