# Rare Entrapment of the Deep Peroneal Nerve by a Ganglion Cyst at the Ankle

**Authors:** Jochen Gerstner Saucedo, Natalia Coriat, Yudel Tamayo, Jorge Moreno, Carlos E Ramirez, Juan Gerstner, Fabiano Nassar de Castro Cardoso

PMC · DOI: 10.7759/cureus.87993 · Cureus · 2025-07-15

## TL;DR

A rare case of deep peroneal nerve entrapment caused by a ganglion cyst at the ankle is reported, highlighting the importance of considering this condition in patients with nerve-related symptoms and soft tissue masses.

## Contribution

This case report adds to the limited literature on ganglion cysts as a cause of deep peroneal nerve entrapment.

## Key findings

- A ganglion cyst was identified as the cause of deep peroneal nerve compression in a 56-year-old woman.
- Surgical excision and nerve decompression led to symptom resolution.
- Ganglion cysts should be included in the differential diagnosis for focal nerve symptoms with soft tissue masses.

## Abstract

Entrapment of the deep peroneal nerve (DPN) is an uncommon yet clinically significant cause of lateral ankle and dorsal foot pain. Among its rare etiologies, ganglion cysts are often overlooked during initial assessments. We present a case of a 56-year-old woman who reported a six-month history of progressive, electric shock-like pain on the dorsum of her left foot, accompanied by a firm mass on the anterolateral ankle. The pain became constant after three months. A physical exam showed a slightly mobile mass and a positive Tinel sign around the DPN. An MRI revealed a cystic lesion compressing the nerve, which led to prompt surgical excision. During the surgery, a hemorrhagic ganglion cyst compressing the DPN was discovered and excised, and nerve decompression was performed. While uncommon, ganglion cysts should be considered in the differential diagnosis for patients exhibiting focal nerve symptoms and soft tissue masses. Timely surgical intervention might help prevent chronic neuropathy and promote functional restoration.

## Full-text entities

- **Diseases:** neuropathy (MESH:D009422), DPN (MESH:C536001), Ganglion Cyst (MESH:D045888), lateral ankle and dorsal foot pain (MESH:D010146), Entrapment of (MESH:D009408), hemorrhagic (MESH:D006470)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12352482/full.md

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Source: https://tomesphere.com/paper/PMC12352482