# Identifying genetic determinants of Mycobacterium tuberculosis acid growth arrest by transposon mutagenesis coupled with next-generation sequencing (Tn-seq)

## TL;DR

This study identifies genes important for Mycobacterium tuberculosis to survive in acidic environments during infection.

## Contribution

The study provides a new high-density transposon mutant sequencing library to identify genes involved in acid growth arrest.

## Key findings

- A transposon mutant sequencing library was generated to identify genetic determinants of acid growth arrest.
- The data set serves as a resource for understanding Mycobacterium tuberculosis adaptation to acidic host niches.

## Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the leading global infectious disease killer. Adaptation of Mycobacterium tuberculosis to acidic niches within the host during infection is vital to establish the disease. Here, we present a high-density transposon mutant sequencing library data set identifying genetic determinants of acid growth arrest to serve as a resource.