# Genomic characterization of Citrobacter freundii clinical isolates from Tanzania

**Authors:** Gerald Mboowa, Benson R. Kidenya, Ivan Sserwadda, Stephen Kanyerezi, Inyasi Lawrence Akaro, Baraka Mkinze, Jeremiah Seni

PMC · DOI: 10.1128/mra.00363-25 · Microbiology Resource Announcements · 2025-07-02

## TL;DR

This study analyzes the genomes of three Citrobacter freundii isolates from Tanzania, revealing antibiotic resistance and virulence traits.

## Contribution

The novelty lies in genomic characterization of C. freundii isolates from Tanzania, revealing multidrug resistance and virulence factors.

## Key findings

- Draft genomes of three C. freundii isolates were sequenced with an average of 6.9 Mb and 51.49% GC content.
- ST167 isolate showed multiple resistance genes and virulence factors, indicating a multidrug-resistant lineage.
- The findings emphasize the importance of genomic surveillance for tracking emerging C. freundii strains.

## Abstract

We report draft genomes of three Citrobacter freundii isolates from Tanzania. Genomes averaged 6.9 Mb with 51.49% GC content and 114× depth. ST167 carried multiple extended-spectrum β-lactamase, fluoroquinolone, and aminoglycoside resistance genes alongside virulence factors, highlighting the need for genomic surveillance of emerging multidrug-resistant C. freundii lineages.

## Linked entities

- **Species:** Citrobacter freundii (taxon 546)

## Full-text entities

- **Chemicals:** GC (MESH:C057580), aminoglycoside (MESH:D000617), fluoroquinolone (MESH:D024841)
- **Species:** Citrobacter freundii (species) [taxon 546]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12352031/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12352031/full.md

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Source: https://tomesphere.com/paper/PMC12352031