The Diagnostic Puzzle of Papillary Thyroid Carcinoma Without Risk Factors

TL;DR

A 12-year-old girl with no known risk factors was diagnosed with papillary thyroid carcinoma, highlighting the challenges in diagnosing this cancer in children.

Contribution

This case report emphasizes the diagnostic complexity of pediatric papillary thyroid carcinoma in the absence of typical risk factors.

Findings

A 12-year-old girl presented with bilateral neck swellings and was diagnosed with papillary thyroid carcinoma.

The case lacked classical risk factors like radiation exposure or family history, making diagnosis challenging.

Timely surgical intervention and follow-up are crucial for favorable outcomes in pediatric thyroid carcinoma.

Abstract

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy in children, yet its diagnosis in pediatric patients can be delayed due to atypical presentations and a low index of clinical suspicion. We report the case of a 12-year-old girl who presented with slowly progressive bilateral neck swellings. There were no classical risk factors such as prior radiation exposure, family history, or symptoms of thyroid dysfunction. Clinical examination and imaging revealed bilateral cervical lymphadenopathy, while initial fine-needle aspiration cytology (FNAC) suggested a benign colloid nodule. However, contrast-enhanced CT of the neck raised suspicion for malignancy, prompting total thyroidectomy with bilateral modified radical neck dissection and central compartment clearance. Histopathological examination confirmed papillary thyroid carcinoma with bilateral lymph node metastases. This case highlights the diagnostic complexity and clinical variability of pediatric PTC, especially in the absence of risk factors. Pediatric thyroid carcinomas, while more likely to present with lymph node involvement and distant spread, generally carry an excellent prognosis with timely intervention. This case emphasizes the need for heightened clinical awareness and an aggressive diagnostic workup, even in seemingly low-risk presentations. Early diagnosis and surgical management, followed by appropriate surveillance, are crucial for ensuring favorable long-term outcomes in pediatric patients with thyroid carcinoma.

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