Role of Gestosis Scoring and Pentamarker in Prediction of Pregnancy-Induced Hypertension (PIH) in Primigravida

TL;DR

This study evaluates gestosis scoring and pentamarker analysis for predicting pregnancy-induced hypertension in first-time pregnant women.

Contribution

The study demonstrates that combining gestosis scores and pentamarker analysis improves early prediction of PIH in primigravida patients.

Findings

29.17% of primigravida patients had high gestosis scores linked to preeclampsia and poor neonatal outcomes.

Positive pentamarker results correlated with increased preeclampsia incidence and NICU admissions.

Combined gestosis and pentamarker assessment improved predictive accuracy for PIH.

Abstract

Introduction: Pregnancy-induced hypertension (PIH) remains a major cause of maternal and fetal complications, highlighting the need for early prediction and intervention. The gestosis score and pentamarker analysis are emerging tools for identifying high-risk pregnancies. This study aims to evaluate the effectiveness of these markers in predicting PIH in primigravida patients to enhance maternal and fetal outcomes.

Objective: The primary objective of this study is to assess the role of the gestosis score and pentamarker in predicting early PIH in primigravida women. By analyzing their predictive accuracy, the study aims to establish these tools as reliable screening methods for timely intervention and management.

Materials and methods: A prospective study was conducted in the Department of Obstetrics and Gynecology at IMS, BHU, in collaboration with the Department of Radiology. A total of 120 first-trimester primigravida women were enrolled. Participants underwent detailed history-taking, clinical examination, and laboratory investigations, including calculation of the gestosis score and Pentamarker analysis. Uterine artery Doppler studies were performed in both the first and second trimesters to assess flow changes. Statistical analysis was conducted to evaluate correlations between these markers and PIH development.

Results: The study found that out of 120 primigravida patients, 29.17% had high gestosis scores, significantly linked to increased risk of preeclampsia and adverse neonatal outcomes. Positive pentamarker reports were also associated with higher preeclampsia incidence and NICU admissions. Combined gestosis score and pentamarker assessment improved predictive accuracy, supporting their role in early PIH detection and management.

Conclusion: Early screening using the gestosis score and pentamarker analysis can help identify primigravida women at risk for PIH, enabling timely intervention. Further studies are needed to validate the effectiveness of these tools in larger populations.

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