# Exploring subthreshold processing for next-generation TinyAI

**Authors:** Farid Nakhle, Antoine H. Harfouche, Hani Karam, Vasileios Tserolas

PMC · DOI: 10.3389/fncom.2025.1638782 · 2025-07-31

## TL;DR

This paper explores how subthreshold processing in biological neurons can inspire energy-efficient AI designs for TinyAI.

## Contribution

The paper introduces novel AI architecture concepts inspired by subthreshold dynamics in biological systems.

## Key findings

- Subthreshold processing in biological systems offers significant energy efficiency for AI.
- Graded activation functions and hybrid systems can emulate biological energy efficiency.
- Neuromorphic hardware may support subthreshold-inspired AI operations.

## Abstract

The energy demands of modern AI systems have reached unprecedented levels, driven by the rapid scaling of deep learning models, including large language models, and the inefficiencies of current computational architectures. In contrast, biological neural systems operate with remarkable energy efficiency, achieving complex computations while consuming orders of magnitude less power. A key mechanism enabling this efficiency is subthreshold processing, where neurons perform computations through graded, continuous signals below the spiking threshold, reducing energy costs. Despite its significance in biological systems, subthreshold processing remains largely overlooked in AI design. This perspective explores how principles of subthreshold dynamics can inspire the design of novel AI architectures and computational methods as a step toward advancing TinyAI. We propose pathways such as algorithmic analogs of subthreshold integration, including graded activation functions, dendritic-inspired hierarchical processing, and hybrid analog-digital systems to emulate the energy-efficient operations of biological neurons. We further explore neuromorphic and compute-in-memory hardware platforms that could support these operations, and propose a design stack aligned with the efficiency and adaptability of the brain. By integrating subthreshold dynamics into AI architecture, this work provides a roadmap toward sustainable, responsive, and accessible intelligence for resource-constrained environments.

## Full-text entities

- **Diseases:** AI (MESH:C538142), arrhythmia (MESH:D001145), CIM (MESH:C000719218)
- **Chemicals:** MoS2 (MESH:C082964), carbon (MESH:D002244), CIM (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12351320/full.md

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Source: https://tomesphere.com/paper/PMC12351320