# Exploring the pathogenesis of acute lung injury and its treatment through Traditional Chinese Medicine: a state-of-the-art review

## TL;DR

This review explores how Traditional Chinese Medicine can treat acute lung injury by analyzing its causes and mechanisms.

## Contribution

A comprehensive analysis of ALI pathogenesis and TCM therapeutic mechanisms from a modern scientific perspective.

## Key findings

- ALI involves immune-inflammatory responses, alveolar-capillary barrier disruption, and gut microbiota alterations.
- TCM strategies like heat-clearing and detoxification show clinical promise in treating ALI.
- Bioactive TCM compounds may offer therapeutic benefits by targeting multiple ALI pathogenic pathways.

## Abstract

Acute Lung Injury (ALI) is a severe and progressive condition characterized by hypoxic respiratory failure, often triggered by multiple contributing factors. It is associated with high morbidity and mortality rates and can advance to Acute Respiratory Distress Syndrome (ARDS) in severe cases. The pathogenesis of ALI involves a complex interplay of pathological mechanisms, including immune-inflammatory responses, disruption of the alveolar-capillary barrier, damage to mesenchymal stem cell organelles, metabolic dysregulation, ferroptosis, and alterations in gut microbiota. From the perspective of Traditional Chinese Medicine (TCM), the development of ALI is primarily attributed to the invasion of toxic pathogens, which result in lung dysfunction. TCM treatment strategies, which emphasize heat-clearing, detoxification, promoting blood circulation, and resolving stasis, have demonstrated promising clinical efficacy. This paper provides a comprehensive analysis of the pathogenesis of ALI and explores the therapeutic mechanisms of TCM compounds and bioactive monomers with potential therapeutic benefits. The goal is to establish a solid theoretical foundation for the clinical application of TCM in ALI treatment and to further validate its scientific rationale.