A cross-sectional study of testosterone deficiency and inflammatory markers in older men

TL;DR

This study explores how low testosterone and inflammation are linked in older men, suggesting a possible connection between testosterone deficiency and metabolic issues.

Contribution

The study identifies a potential association between testosterone deficiency and elevated inflammatory markers in aging men.

Findings

Higher hsCRP levels correlate with increased BMI and unfavorable metabolic profiles in men without testosterone deficiency.

Testosterone deficiency and elevated inflammation markers are linked to worse metabolic and body measurements.

The study highlights the need for further research into the biological pathways connecting inflammation and testosterone deficiency.

Abstract

This cross-sectional study aimed to examine the relationship between total testosterone (TT) levels, the diagnosis of testosterone deficiency syndrome (TDS), and high-sensitivity C-reactive protein (hsCRP) concentrations in aging men. The analysis also included selected hormonal and anthropometric parameters.

Serum hsCRP levels were measured. Additionally, serum levels of TT, estradiol (E2), dehydroepiandrosterone sulfate (DHEA-S), insulin (I), and sex hormone-binding protein (SHBG) were assessed using ELISA. Patients were divided based on the presence or absence of a TDS diagnosis.

In patients without TDS, no significant correlation was observed between hsCRP levels and other measured variables. However, higher hsCRP levels were associated with an increased BMI, larger waist and hip circumferences, and elevated triglyceride (TAG) levels compared to patients with lower hsCRP concentrations.

The co-occurrence of testosterone deficiency and elevated inflammatory markers such as hsCRP was associated with less favorable metabolic and anthropometric profiles. While causality cannot be inferred from this observational study, the findings suggest a possible link between systemic inflammation and testosterone deficiency in aging men. These associations merit further investigation in longitudinal and mechanistic studies to clarify directionality and underlying biological pathways.

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