# Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review

## TL;DR

This paper reports a rare case of mixed adenoneuroendocrine carcinoma in the gallbladder and reviews existing literature to improve understanding of its diagnosis and treatment.

## Contribution

The novelty lies in presenting a rare gallbladder tumor case and reviewing literature to guide future diagnosis and treatment.

## Key findings

- MANEC was confirmed in the gallbladder with no metastasis to the liver or lymph nodes.
- The case highlights the rarity and high malignancy of gallbladder-originating MANEC.
- Literature review suggests the need for improved diagnostic and therapeutic strategies for this tumor.

## Abstract

Adenocarcinoma (AC) and neuroendocrine carcinoma (NEC) in the gallbladder originate from glandular epithelium and neuroendocrine cells, respectively. AC and NEC are called mixed AC-NEC (MANEC) when they occur in the same tumor. The present study presents the case of a 57-year-old female individual who was diagnosed with gallbladder space. Gallbladder, S4b+5 resection of liver and hepatic pedicle lymph -node dissection were performed. Postoperative pathology confirmed MANEC in the gallbladder. No metastasis was found in the liver and pedicle lymph nodes. Given the rarity and high degree of malignancy of MANEC originating in the gallbladder, the previous literature was reviewed to enhance the understanding of the diagnosis and treatment of this tumor.