# Giant Breast Myofibroblastoma: A Rare Case of Benign Breast Tumor in a Postmenopausal Woman

**Authors:** Henry I. Lyimo, Zephania D. P. Gega, Alex B. Mashaka, Angela T. Mlole, Saida K. Abeid, Petro J. Mabindi, Nashivai E. Kivuyo, Ally H. Mwanga

PMC · DOI: 10.1155/cris/9930606 · 2025-08-06

## TL;DR

A rare case of a benign breast tumor called myofibroblastoma is reported in a postmenopausal woman, emphasizing the need for accurate diagnosis through tissue biopsy.

## Contribution

This paper presents a rare clinical case of breast myofibroblastoma in a postmenopausal woman, highlighting diagnostic challenges and management.

## Key findings

- Breast myofibroblastoma can mimic malignant tumors but is benign.
- Accurate diagnosis requires histopathology and immunohistochemistry.
- Simple mastectomy was curative in this case.

## Abstract

Introduction: Breast myofibroblastoma (MFB) is a relatively rare benign tumor that mimics the clinical presentation of malignant tumors of the breast. It has various morphologic variants that can be accurately diagnosed based on histopathology and immunohistochemistry staining. We report a case of MFB in a menopausal woman for pertinent clinical consideration and management.

Case Presentation: We report a case of a 57-year-old Tanzanian woman, who presented with a huge right breast mass for 1 year. Initial radiological findings were inconclusive, however, the tissue specimen for histology and immunohistochemical (IHC) confirmed the diagnosis. A simple mastectomy was thereafter performed as a curative therapy.

Conclusion: This case presentation underscores the importance of considering MFB as a potential differential for breast tumors especially in menopausal women. Tissue biopsy for histopathology and IHC staining form the cornerstone for accurate diagnosis and appropriate management.

## Linked entities

- **Diseases:** breast tumor (MONDO:0007254), myofibroblastoma (MONDO:0021545)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** mucin [NCBI Gene 100508689], S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, VIM (vimentin) [NCBI Gene 7431], CD34 (CD34 molecule) [NCBI Gene 947], SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}
- **Diseases:** fibroepithelial (MESH:D018225), Mesenchymal tumor (MESH:C535700), MFB (MESH:D009379), trauma (MESH:D014947), blood loss (MESH:D016063), icterus (MESH:D007565), lymphadenopathy (MESH:D008206), benign (MESH:D009369), abortion (MESH:D000026), uterine myoma (MESH:D009214), fibroadenoma (MESH:D018226), Breast MFB (MESH:D061325), Breast Tumor (MESH:D001943), pulmonary lesions (MESH:D008171), fever (MESH:D005334), anemia (MESH:D000740), spindle cell lesions (MESH:D002277), weight loss (MESH:D015431)
- **Chemicals:** proline (MESH:D011392), alcohol (MESH:D000438)
- **Species:** Human immunodeficiency virus 1 (no rank) [taxon 11676], Homo sapiens (human, species) [taxon 9606]

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12350007/full.md

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Source: https://tomesphere.com/paper/PMC12350007