# Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update

**Authors:** Florencia Barrios, Paul Ruiz, Juan Pablo Damián

PMC · DOI: 10.1155/vmi/9109397 · 2025-08-06

## TL;DR

This paper reviews how to manage fear, anxiety, and stress in domestic cats, emphasizing their unique emotional systems and offering practical solutions.

## Contribution

The paper provides updated insights and recommendations for understanding and managing feline emotional responses, including cat-friendly environments and pharmacological approaches.

## Key findings

- Fear, anxiety, and stress are common behavioral problems in domestic cats due to their distinct emotional systems.
- Creating a 'cat-friendly' environment is recommended to improve human–cat coexistence and reduce stress.
- Pharmacological management can help ensure stress-free veterinary visits for cats and their caretakers.

## Abstract

Domestic cats are one of the most popular pets worldwide. Despite their growing popularity, there remains a significant gap in understanding their specific needs, leading to frequent challenges in human–cat coexistence and behavioral issues. The distinct emotional systems of cats, compared to other domestic species and humans, complicate the interpretation of feline behavior. Notably, fear, anxiety, and stress are among the most prevalent behavioral problems in cats. This review delves into the core concepts of anxiety, fear, and stress responses in domestic cats, highlighting their unique characteristics and providing recommendations for effective handling. Additionally, it presents some key international recommendations for creating a “cat-friendly” environment, as well as suggestions for pharmacological management to ensure a stress-free visit to the clinic for the cat, its caretaker, and the veterinary team.

## Full-text entities

- **Genes:** MAO-A [NCBI Gene 101091848], MAO-B [NCBI Gene 101092086], CRH [NCBI Gene 692345]
- **Diseases:** skin lesions (MESH:D012871), Deterioration (MESH:D000075902), dental disorders (MESH:D009057), lethargy (MESH:D053609), compromised liver function (MESH:D056486), tremors (MESH:D014202), inflammatory (MESH:D007249), organic diseases (MESH:D000092124), serotonin syndrome (MESH:D020230), hyperphagia (MESH:D006963), chronic pain (MESH:D059350), social (OMIM:300082), CDS (MESH:C536560), multiple sclerosis (MESH:D009103), epilepsy (MESH:D004827), cognitive dysfunction (MESH:D003072), vomiting (MESH:D014839), mydriasis (MESH:D015878), decreased appetite (MESH:D001068), Problems (MESH:D019973), motion sickness (MESH:D009041), FIC (MESH:D018856), compulsive behaviors (MESH:D003193), depression (MESH:D003866), Phobias (MESH:D010698), Alzheimer's disease (MESH:D000544), Learned helplessness (MESH:D007859), analgesia (MESH:D000699), nausea (MESH:D009325), white coat syndrome (MESH:D059466), diarrhea (MESH:D003967), Gastrointestinal disorders (MESH:D005767), seizures (MESH:D012640), heart disease (MESH:D006331), drooling (MESH:D012798), cystitis (MESH:D003556), hyperthyroidism (MESH:D006980), anxiety disorders (MESH:D001008), behavioral abnormalities (MESH:D001523), Pain (MESH:D010146), compulsions (MESH:D000073932), mental health disorder (OMIM:603663), anorexia (MESH:D000855), neurological disease (MESH:D020271), hyperglycemia (MESH:D006943), glaucoma (MESH:D005901), panic (MESH:D016584), tachycardia (MESH:D013610), Anxiety (MESH:D001007), urine (MESH:D014555), PTSD (MESH:D013313), emotional disorders (MESH:D009358), urinary tract infection (MESH:D014552), confusion (MESH:D003221), neurological illnesses (MESH:D009461), hepatic lipidosis (MESH:D008064), Defensive aggression (MESH:D010554), toxicity (MESH:D064420), ataxia (MESH:D001259), Parkinson's disease (MESH:D010300)
- **Chemicals:** catecholamines (MESH:D002395), midazolam (MESH:D008874), flumazenil (MESH:D005442), L-Tryptophan (MESH:D014364), minerals (MESH:D008903), alpha-amino acid (MESH:D000596), Fluoxetine (MESH:D005473), Dexmedetomidine (MESH:D020927), Buspirone (MESH:D002065), norepinephrine (MESH:D009638), acid (MESH:D000143), glucose (MESH:D005947), butorphanol (MESH:D002077), Venlafaxine (MESH:D000069470), Pregabalin (MESH:D000069583), Melatonin (MESH:D008550), lorazepam (MESH:D008140), atipamezole (MESH:C050701), GABA (MESH:D005680), naloxone (MESH:D009270), sertraline (MESH:D020280), serotonin (MESH:D012701), L-Theanine (MESH:C026166), cortisol (MESH:D006854), Clomipramine (MESH:D002997), medetomidine (MESH:D020926), mirtazapine (MESH:D000078785), Cerenia (MESH:C518176), 5-HTP (MESH:D006916), diazepam (MESH:D003975), morphine (MESH:D009020), Paroxetine (MESH:D017374), Endocannabinoid (MESH:D063388), amitraz (MESH:C014983), CBD (MESH:D002185), Gabapentin (MESH:D000077206), Benzodiazepines (MESH:D001569), Selegiline (MESH:D012642), Ketamine (MESH:D007649), SARI (-), Trazodone (MESH:D014196), Dopaminergic (MESH:D004298)
- **Species:** Bos taurus (bovine, species) [taxon 9913], Felis silvestris lybica (Near Eastern wildcat, subspecies) [taxon 61377], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615], Sus scrofa (pig, species) [taxon 9823]

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Source: https://tomesphere.com/paper/PMC12349988