# Adenovirus Disease and Ocular Symptoms in Children: Diagnosis and Prognostic Considerations

**Authors:** Jannatul Fardous, Arpita Goutam, Tajrin Rahman, Zahid Hasan Khan, Sabrina Nahin, Sumaiya Hussain, Mohammad Safiul Bashar Khan, Mohammad Delwer Hossain Hawlader, Mohammad Ashraful Amin

PMC · DOI: 10.1155/crdi/2621782 · 2025-08-06

## TL;DR

This paper discusses a case of adenovirus in a child with multiple symptoms and raises questions about possible links to other conditions.

## Contribution

The paper presents a unique case highlighting the complex manifestations of adenoviral infections and suggests potential associations with undescended testes and scoliosis.

## Key findings

- A 14-year-old male presented with adenoviral pharyngoconjunctival fever and subconjunctival hemorrhage.
- The patient also had undescended testes and scoliosis, prompting questions about possible correlations.
- Comprehensive evaluation is emphasized for accurate diagnosis and management of adenoviral infections in children.

## Abstract

Adenoviral infections significantly impact pediatric health, manifesting as respiratory, gastrointestinal, and ocular disorders. We report a 14-year-old male with adenoviral pharyngoconjunctival fever (PCF) complicated by subconjunctival hemorrhage and enlarged adenoids. The patient presented with high-grade fever, sore throat, bilateral conjunctivitis, and gastrointestinal symptoms, including vomiting and diarrhea. Initial laboratory findings suggested septicemia; however, an extended respiratory panel confirmed adenoviral infection. Notably, the patient also had left-sided undescended testes and scoliosis, raising questions about potential associations. This case underscores the complexity of adenoviral infections in children, highlighting the interplay of respiratory, gastrointestinal, and ocular symptoms. The presence of additional conditions warrants further investigation into possible correlations with adenoviral infection. Comprehensive evaluation is crucial for accurate diagnosis and management of adenoviral infections in pediatric patients, and future research should explore long-term implications and associations with cryptorchidism and scoliosis.

## Linked entities

- **Diseases:** pharyngoconjunctival fever (MONDO:0005911), cryptorchidism (MONDO:0009047), scoliosis (MONDO:0005392)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** pharyngitis (MESH:D010612), infectious disease (MESH:D003141), congenital abnormalities (MESH:D000013), inflammation (MESH:D007249), glaucoma (MESH:D005901), abdominal pain (MESH:D015746), COVID-19 (MESH:D000086382), photophobia (MESH:D020795), EKC (MESH:D007637), cryptorchidism (MESH:D003456), vomiting (MESH:D014839), Scoliosis (MESH:D012600), chills (MESH:D023341), viral conjunctivitis (MESH:D003236), keratitis (MESH:D007634), Adenoviral conjunctivitis (MESH:D003231), Acute follicular conjunctivitis (MESH:D003232), TB (MESH:D014376), hypogonadism (MESH:D007006), PCF (MESH:D005334), respiratory tract infection (MESH:D012141), leukocytosis (MESH:D007964), skeletal development disturbances (MESH:D002658), bronchial asthma (MESH:D001249), febrile (MESH:D000071072), CMV (MESH:D003586), dehydration (MESH:D003681), lid swelling (MESH:D004409), bacterial (MESH:D001424), conjunctival congestion (MESH:D003229), cytotoxic (MESH:D064420), ocular infection (MESH:D015817), lymphadenopathy (MESH:D008206), meningeal irritation (MESH:D008580), Adenoviral infections (MESH:D007239), diarrhea (MESH:D003967), Adenovirus Disease (MESH:D000257), respiratory and allergic symptoms (MESH:D012818), retarded epididymal development (MESH:D004823), gastrointestinal symptoms (MESH:D012817), septicemia (MESH:D018805), hemorrhage (MESH:D006470), gastrointestinal complaints (MESH:D005767), weight loss (MESH:D015431), Viral infections (MESH:D014777), muscular weakness (MESH:D018908), watery diarrhea (MESH:D003969)
- **Chemicals:** estradiol (MESH:D004958), ondansetron (MESH:D017294), levocetirizine (MESH:C472067), Montelukast (MESH:C093875), Acyclovir (MESH:D000212), Moxifloxacin (MESH:D000077266), DNS (MESH:C022306), sucralfate (MESH:D013392), Carboxymethylcellulose sodium (MESH:D002266), carbapenem (MESH:D015780), Ciprofloxacin (MESH:D002939), oxygen (MESH:D010100)
- **Species:** Bacillus sp. CG (species) [taxon 1196795], Homo sapiens (human, species) [taxon 9606], Adenoviridae (family) [taxon 10508]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12349980/full.md

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Source: https://tomesphere.com/paper/PMC12349980