# Harnessing AI for Improved Detection and Classification of Pleural Effusion: Insights and Innovations

**Authors:** Geran Maule, Ahmad Alomari, Abdallah Rayyan, Ogbeide Aghahowa, Mohammad Khraisat, Luis Javier

PMC · DOI: 10.1155/carj/2882255 · 2025-08-06

## TL;DR

This paper explores how AI can improve the detection and classification of pleural effusion, a condition that is often hard to diagnose and can lead to poor patient outcomes.

## Contribution

The paper provides a synthesis of AI applications for pleural effusion detection, highlighting high-performing models and the value of integrating diverse diagnostic data.

## Key findings

- AI models like LGB and XGBoost achieved up to 96% accuracy in pleural effusion detection.
- High AUC values (e.g., 0.883) demonstrate strong performance in differentiating pleural effusion types.
- Integrating clinical, lab, and imaging data improves diagnostic accuracy for pleural effusion.

## Abstract

The detection and classification of pleural effusion present significant challenges in clinical practice, often contributing to delayed diagnoses and suboptimal patient outcomes. Recent advancements in artificial intelligence (AI) and machine learning (ML) techniques hold substantial promise for enhancing the accuracy and efficiency of pleural effusion diagnostics. This paper reviews the current landscape of AI applications in pleural effusion detection, synthesizing findings across diverse studies to illustrate the transformative potential of these technologies. We examine various ML models, including deep learning and ensemble methods, that leverage clinical, laboratory, and imaging data to improve diagnostic performance. Notably, models such as Light Gradient Boosting Machine (LGB) and XGBoost have achieved accuracy levels up to 96% and high AUC values (e.g., AUC = 0.883 for pleural effusion differentiation). This overview highlights the importance of integrating diverse diagnostic parameters to enhance pleural effusion diagnostic accuracy and outlines future research directions essential for optimizing patient management and outcomes.

## Full-text entities

- **Genes:** MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, ADA (adenosine deaminase) [NCBI Gene 100] {aka ADA1}
- **Diseases:** malignant pleural effusion (MESH:D016066), DL (MESH:D007859), effusion (MESH:D000080324), heart failure (MESH:D006333), infections (MESH:D007239), Pleural Effusion (MESH:D010996), Tumor (MESH:D009369), LGB (MESH:D000141)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12349979