# Synthesis of Gadolinium-Loaded Poly(N-vinyl-2-pyrrolidone) Nanogels Using Pulsed Electron Beam Ionizing Irradiation

## TL;DR

This paper describes a method to create nanogels loaded with gadolinium using electron beam irradiation, which could be useful for MRI applications.

## Contribution

The study introduces a novel synthesis method for Gd-loaded PVP nanogels using pulsed electron beam irradiation.

## Key findings

- PVP and Gd ions form a complex before irradiation.
- Nanogel size depends on PVP molecular weight, concentration, temperature, and Gd addition timing.
- The study quantifies factors affecting free Gd ion concentration.

## Abstract

Poly(N-vinyl-2-pyrrolidone), or PVP, nanogels loaded with gadolinium nitrate (Gd(NO3)3·6H2O) were synthesized by ionizing irradiation, aiming for potential applications in magnetic resonance imaging (MRI). A comprehensive characterization of PVP and Gd aqueous solutions with different VP-monomer-to-Gd ratios was conducted before and after irradiation. The results indicate a complexation between PVP and Gd ions before irradiation. The size of the nanogels exhibited a strong dependence on several factors, including PVP molecular weight, concentration, temperature, and the precise timing of Gd introduction relative to the irradiation process. A quantification study was conducted to investigate the impact of molecular weight, the VP/Gd ratio, and Gd addition before or after the irradiation process on the concentration of free Gd ions. These findings offer valuable insights into optimizing the synthesis of Gd-loaded PVP nanogels for potential applications, highlighting the critical factors that influence their size and stability.