# Endonephrology: Evolving Techniques of Endoscopic Ultrasound in Diagnosing Renal Lymphoma

**Authors:** Erika Tsuchiyose, Michael Talanian, Erik Holzwanger

PMC · DOI: 10.14309/crj.0000000000001815 · 2025-08-13

## TL;DR

The paper discusses a rare case where endoscopic ultrasound was used to diagnose lymphoma in the kidney.

## Contribution

It presents a novel application of endoscopic ultrasound for renal tissue sampling in a complex patient case.

## Key findings

- Endoscopic ultrasound can overcome limitations of traditional imaging for renal mass evaluation.
- A case of renal lymphoma was successfully diagnosed using endoscopic ultrasound-guided tissue acquisition.

## Abstract

Mucosa-associated lymphoid tissue lymphoma is a subtype of non-Hodgkin lymphoma, exceedingly rare when originating in the kidney. Most renal masses are percutaneously sampled with ultrasound or computed tomography guidance; however, limitations can include location, size, and body habitus, which may be resolved using endoscopic ultrasound–guided approaches. We present an unusual case of a 77-year-old man with history of systemic lupus erythematosus, duodenal mucosa–associated lymphoid tissue lymphoma in remission, and rectal adenocarcinoma who presented for evaluation of a right renal mass, which highlights the novelty of endoscopic ultrasound–guided renal evaluation and tissue acquisition.

## Linked entities

- **Diseases:** systemic lupus erythematosus (MONDO:0007915), mucosa-associated lymphoid tissue lymphoma (MONDO:0007650), rectal adenocarcinoma (MONDO:0002169)

## Full-text entities

- **Genes:** KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, IL9 (interleukin 9) [NCBI Gene 3578] {aka HP40, IL-9, P40}, CD5 (CD5 molecule) [NCBI Gene 921] {aka LEU1, T1}, FCER2 (Fc epsilon receptor II) [NCBI Gene 2208] {aka BLAST-2, CD23, CD23A, CLEC4J, FCE2, FCErII}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, BCL6 (BCL6 transcription repressor) [NCBI Gene 604] {aka BCL5, BCL6A, LAZ3, ZBTB27, ZNF51}, MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}, SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}, SPN (sialophorin) [NCBI Gene 6693] {aka CD43, GALGP, GPL115, LEU-22, LSN}
- **Diseases:** Duodenal MALT lymphoma (MESH:D018442), prostate cancer (MESH:D011471), Hashimoto's thyroiditis (MESH:D050031), minimal change disease (MESH:D009402), Helicobacter pylori infection (MESH:D016481), Renal mass (MESH:C536030), luminal disease (MESH:D004194), renal involvement (MESH:C565423), chronic inflammation (MESH:D007249), Non-Hodgkin lymphoma (MESH:D008228), malignancy (MESH:D009369), Sjogren syndrome (MESH:D012859), bleeding (MESH:D006470), infection (MESH:D007239), SLE (MESH:D008180), lymphadenopathy (MESH:D008206), Renal Lymphoma (MESH:D008223), B-cell lymphoma (MESH:D016393), sarcoidosis (MESH:D012507), right (MESH:C535682), mediastinal lymphadenopathy (MESH:D008477), tuberculosis (MESH:D014376), granulomatous disorders (MESH:D006105), IgA nephropathy (MESH:D005922), renal cancers (MESH:D007680), rectal adenocarcinoma (MESH:D000230), autoimmune (MESH:D001327)
- **Chemicals:** FDG (MESH:D019788), bendamustine (MESH:D000069461), cyclophosphamide, vincristine, and prednisone (-), rituximab (MESH:D000069283)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12348391/full.md

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Source: https://tomesphere.com/paper/PMC12348391