# Vascular Access for Hemodialysis and Right Ventricular Remodeling: A Prospective Echocardiographic Study

## TL;DR

This study found that creating vascular access for hemodialysis causes heart changes, especially in the right ventricle, linked to fluid overload and heart pressure.

## Contribution

The study identifies fluid overload and left ventricular filling pressure as key drivers of right ventricular remodeling after AVF creation in ESKD patients.

## Key findings

- Right ventricular remodeling was most pronounced and linked to volume overload and elevated left ventricular filling pressure.
- Moderate AVF flow was associated with biventricular dilatation but not with significant changes in systolic function.
- Fluid management and vascular access planning are critical to mitigate cardiac remodeling in ESKD patients.

## Abstract

Background: Arteriovenous fistulas (AVFs) may contribute to cardiac remodeling and consequently to an increased risk of heart failure and cardiovascular mortality in patients with end-stage kidney disease (ESKD). We aimed to assess cardiac changes following AVF creation and identify potential parameters associated with cardiac remodeling. Methods: In our prospective, single-center study, ESKD patients without significant pre-existing cardiac disease underwent 2D and 3D echocardiographic evaluation before and after AVF creation, along with AVF flow measurement. Cardiac remodeling was assessed using 3D indexed left and right ventricular end-diastolic volumes (LVEDVi, RVEDVi), while systolic function was assessed using longitudinal strain and 3D ejection fraction. Results: We included 20 patients (18 men; median age 73.5 years [IQR: 67–77]) with a mean AVF flow of 1140 ± 345 mL/min. At a median of 8.2 months (IQR: 7.3–9.3) following AVF creation, significant biventricular dilatation was observed: LVEDVi increased from 89 ± 14 to 97 ± 21 mL/m2 (p < 0.05) and RVEDVi from 80 ± 15 to 91 ± 18 mL/m2 (p < 0.05), while the systolic function of both ventricles did not change significantly. The right ventricle showed the most pronounced remodeling and it was independently associated with volume overload (p = 0.003) and elevated left ventricular filling pressure (p = 0.030), but not with AVF flow. Conclusions: Moderate AVF flow was associated with cardiac remodeling, primarily affecting the right ventricle. Fluid overload and left ventricular filling pressure were key factors associated with right ventricular remodeling, underscoring the need for careful fluid management and vascular access planning in ESKD patients.