# The Role of Biodegradable Temporizing Matrix in Paediatric Reconstructive Surgery

**Authors:** Aikaterini Bini, Michael Ndukwe, Christina Lipede, Ramesh Vidyadharan, Yvonne Wilson, Andrea Jester

PMC · DOI: 10.3390/jcm14155427 · Journal of Clinical Medicine · 2025-08-01

## TL;DR

This paper explores the use of a biodegradable matrix in pediatric reconstructive surgery, showing it can lead to good healing with minimal complications.

## Contribution

The study provides novel insights into the application and outcomes of BTM in a pediatric population for reconstructive surgery.

## Key findings

- BTM showed acceptable aesthetic and functional outcomes in pediatric patients.
- Complications were rare, including infection and graft failure in a small number of cases.
- BTM offers advantages like reduced infection risk and no donor site morbidity in children.

## Abstract

Introduction: Biodegradable Temporizing Matrix (BTM) is a new synthetic dermal substitute suitable for wound closure and tissue regeneration. The data in paediatric population remain limited. The study purpose is to review the indications for BTM application in paediatric patients, evaluate the short-term and long-term results, including complications and functional outcomes, as well as to share some unique observations regarding the use of BTM in paediatric population. Patients and Methods: Patients undergoing reconstructive surgery and BTM application during the last three years were included. Data collected included patient demographics, primary diagnosis, previous surgical management, post-operative complications and final outcomes. BTM was used in 32 patients. The indications varied including epidermolysis bullosa (n = 6), burns (n = 4), trauma (n = 7), infection (n = 4), ischemia or necrosis (n = 11). Results: The results were satisfying with acceptable aesthetic and functional outcomes. Complications included haematoma underneath the BTM leading to BTM removal and re-application (n = 1), BTM infection (n = 1) and split-thickness skin graft failure on top of BTM requiring re-grafting (n = 2). Conclusions: BTM can be a good alternative to large skin grafts, locoregional flaps or even free flaps. The big advantages over other dermal substitutes or skin grafts are that BTM is less prone to infection and offers excellent scarring by preserving the normal skin architecture. Specifically in children, BTM might not require grafting, resulting in spontaneous healing with good scarring. In critically ill patients, BTM reduces the operation time and there is no donor site morbidity. BTM should be considered in the reconstructive ladder when discussing defect coverage options in children and young people.

## Linked entities

- **Diseases:** epidermolysis bullosa (MONDO:0006541), burns (MONDO:0043519), infection (MONDO:0005550)

## Full-text entities

- **Diseases:** ischemia (MESH:D007511), critically ill (MESH:D016638), burns (MESH:D002056), necrosis (MESH:D009336), infection (MESH:D007239), epidermolysis bullosa (MESH:D004820), trauma (MESH:D014947)
- **Chemicals:** BTM (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12347558/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC12347558/full.md

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Source: https://tomesphere.com/paper/PMC12347558