# Profiling the Expression Level of a Gene from the Caspase Family in Triple-Negative Breast Cancer

## TL;DR

This study examines how the expression levels of caspase family genes relate to triple-negative breast cancer and could help in personalized treatment.

## Contribution

The study identifies potential correlations between caspase gene expression and the clinical course of triple-negative breast cancer.

## Key findings

- Expression levels of caspase family genes correlate with the clinical course of TNBC.
- Results suggest that profiling these genes could aid in personalized treatment selection.
- Findings were compared with data from the Cancer Genome Atlas and other tools.

## Abstract

It is believed that caspases may play a significant role in the development of cancer, and the expression levels of genes encoding these proteins may influence the prognosis and clinical course of cancer. Taking into account the information presented, we examined the expression profiles of 11 genes from the caspase family in patients diagnosed with triple-negative breast cancer (TNBC). We qualified 29 patients with TNBC. A fragment of the tumor and a fragment of normal tissue surrounding the tumor were collected from each patient. Then, RNA was isolated, and the reverse transcription process was performed. The expression levels of caspase family genes were determined using the real-time PCR method. The obtained data were correlated with clinical data and compared with data from the Cancer Genome Atlas database using the Breast Cancer Gene Expression Miner v4.8 and Ualcan. Based on the results of the conducted research, it can be assumed that the levels of expression of caspase family genes may be correlated with the clinical course of cancer in patients with TNBC, and further research may indicate that profiling the expression levels of these genes may be used in selecting personalized treatment methods.