# Molecular Foundations of Neuroplasticity in Brain Tumours: From Microscopic Adaptation to Functional Reorganisation

## TL;DR

This paper reviews how brain tumors trigger molecular changes that lead to neuroplasticity, helping preserve brain function despite tumor growth.

## Contribution

The paper provides a comprehensive synthesis of molecular mechanisms linking microscopic adaptations to macroscopic functional reorganisation in brain tumors.

## Key findings

- Stress-regulated molecules and synaptic proteins play key roles in neuroplasticity during tumor growth.
- Trophic factors and morphological changes contribute to adaptive brain responses.
- Bridging microscopic and macroscopic plasticity could improve clinical outcomes for brain tumor patients.

## Abstract

Brain tumours challenge the structural and functional integrity of the brain, yet remarkable neuroplastic adaptations often preserve critical functions. This review synthesises the current knowledge of the molecular events underlying neuroplasticity in the context of tumoural growth, spanning from early genetic and protein alterations to macroscopic functional reorganisation. We discuss the roles of stress-regulated molecules, synaptic proteins, trophic factors, and morphological changes in driving adaptive responses. Furthermore, we bridge the gap between microscopic molecular events and large-scale network adaptations, emphasising clinical implications for glioma surgery and patient outcomes. Despite advances, knowledge gaps persist regarding the dynamics, predictors, and therapeutic modulation of plasticity, underscoring the need for future longitudinal and translational research. Understanding and leveraging these molecular mechanisms holds promise for improving functional recovery and quality of life in patients with brain tumours.